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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
32
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|
pubmed:dateCreated |
2001-9-5
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|
pubmed:abstractText |
Development of a safe and immunogenic tetravalent dengue virus (DV) vaccine has been designated as a priority by the World Health Organization. We characterized the T cell response to DV induced by a candidate live attenuated tetravalent DV vaccine as part of a phase I study. Proliferation and cytotoxic T lymphocyte (CTL) responses to multiple DV serotypes were detected in six of six and four of four subjects studied, respectively. Proliferation responses were higher to DV serotypes 1 and 3 than to serotypes 2 and 4. CTL responses were higher to DV serotypes 2 and 3 than to serotype 1, and included serotype cross-reactive responses. Production of interferon-gamma, but not IL-4, was observed in response to DV stimulation. This candidate vaccine is immunogenic for both CD4+ and CD8+ T lymphocytes. However, T cell responses to the four DV serotypes were not equivalent, suggesting that the vaccine could be further optimized.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0264-410X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
14
|
|
pubmed:volume |
19
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
4694-9
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|
pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11535318-Antibodies, Viral,
pubmed-meshheading:11535318-B-Lymphocytes,
pubmed-meshheading:11535318-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11535318-Culture Media, Conditioned,
pubmed-meshheading:11535318-Cytokines,
pubmed-meshheading:11535318-Cytotoxicity, Immunologic,
pubmed-meshheading:11535318-Dengue Virus,
pubmed-meshheading:11535318-Genetic Variation,
pubmed-meshheading:11535318-Humans,
pubmed-meshheading:11535318-Immunologic Memory,
pubmed-meshheading:11535318-Interferon-gamma,
pubmed-meshheading:11535318-Interleukin-4,
pubmed-meshheading:11535318-Lymphocyte Activation,
pubmed-meshheading:11535318-Neutralization Tests,
pubmed-meshheading:11535318-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:11535318-Vaccination,
pubmed-meshheading:11535318-Vaccines, Attenuated,
pubmed-meshheading:11535318-Vaccinia virus,
pubmed-meshheading:11535318-Viral Vaccines
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pubmed:year |
2001
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|
pubmed:articleTitle |
Induction of T lymphocyte responses to dengue virus by a candidate tetravalent live attenuated dengue virus vaccine.
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|
pubmed:affiliation |
Center for Infectious Disease and Vaccine Research, Rm. S5-326, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. alan.rothman@umassmed.edu
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|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase I
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