Source:http://linkedlifedata.com/resource/pubmed/id/11534990
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2001-9-5
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| pubmed:abstractText |
We examined effects of a wide range of doses of three man-made estrogenic chemicals during fetal life on neurobehavioral changes during early postnatal life in mice. Pregnant mice were fed a 4-log range of o,p'DDT, methoxychlor (MXC), and the drug diethystilbestrol (DES) from gestation days 11 to 17. Offspring were examined for changes in postnatal growth and the development of neuromuscular reflexes. Fetal exposure to the estrogenic chemicals altered the number of live pups per litter, the sex ratio of the litters, the anogenital distance of male and female offspring at birth (a bioassay for fetal androgen action), and the body weight of offspring at birth and during the first 5 days of postnatal life. In most cases, however, the dose-response relationships were complex (non-monotonic), with effects at the highest dose examined being opposite to effects seen at lower doses. The two markers of neurobehavioral development, righting and cliff avoidance reflexes, were not sensitive indicators of prenatal estrogen exposure. Only maternal exposure to the lowest MXC dose produced an increase in reactivity in righting and cliff avoidance tests in offspring.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/DDT,
http://linkedlifedata.com/resource/pubmed/chemical/Diethylstilbestrol,
http://linkedlifedata.com/resource/pubmed/chemical/Insecticides,
http://linkedlifedata.com/resource/pubmed/chemical/Methoxychlor
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| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0018-506X
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2001 Academic Press.
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| pubmed:issnType |
Print
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| pubmed:volume |
40
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
252-65
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:11534990-Animals,
pubmed-meshheading:11534990-Animals, Newborn,
pubmed-meshheading:11534990-Avoidance Learning,
pubmed-meshheading:11534990-Behavior, Animal,
pubmed-meshheading:11534990-Body Weight,
pubmed-meshheading:11534990-Carcinogens,
pubmed-meshheading:11534990-DDT,
pubmed-meshheading:11534990-Diethylstilbestrol,
pubmed-meshheading:11534990-Female,
pubmed-meshheading:11534990-Genitalia,
pubmed-meshheading:11534990-Insecticides,
pubmed-meshheading:11534990-Litter Size,
pubmed-meshheading:11534990-Male,
pubmed-meshheading:11534990-Methoxychlor,
pubmed-meshheading:11534990-Mice,
pubmed-meshheading:11534990-Nervous System,
pubmed-meshheading:11534990-Postural Balance,
pubmed-meshheading:11534990-Pregnancy,
pubmed-meshheading:11534990-Prenatal Exposure Delayed Effects,
pubmed-meshheading:11534990-Sex Ratio,
pubmed-meshheading:11534990-Survival Analysis
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| pubmed:year |
2001
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| pubmed:articleTitle |
Effects of prenatal exposure to low doses of diethylstilbestrol, o,p'DDT, and methoxychlor on postnatal growth and neurobehavioral development in male and female mice.
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| pubmed:affiliation |
Dipartimento di Biologia Evolutiva e Funzionale, University of Parma, 43100 Parma, Italy. Palanza@biol.unipr.it
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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