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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0036341,
umls-concept:C0039729,
umls-concept:C0185117,
umls-concept:C0243046,
umls-concept:C0681850,
umls-concept:C0949771,
umls-concept:C1519595,
umls-concept:C1550501,
umls-concept:C1706203,
umls-concept:C2349001,
umls-concept:C2697811,
umls-concept:C2911684
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pubmed:issue |
9
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pubmed:dateCreated |
2001-9-4
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pubmed:abstractText |
Recent investigations of schizophrenia have targeted glutamatergic neurotransmission, since phencyclidine, an N-methyl-D-aspartate (NMDA) receptor antagonist, can induce schizophreniform psychosis. The authors previously reported alterations in thalamic NMDA receptor subunit expression in schizophrenia, consistent with the hypothesis that thalamic glutamatergic hypofunction may contribute to the pathophysiology of this illness. In this study they generalized this hypothesis to include other molecules of the glutamate synapse, specifically excitatory amino acid transporters (EAATs), whose normal expression and regulation in the thalamus may also be disrupted in subjects with schizophrenia.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acid Transport System X-AG,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Transporter 1,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Transporter 2,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Transporter 3,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamate Plasma Membrane...,
http://linkedlifedata.com/resource/pubmed/chemical/Grin3a protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neurotransmitter,
http://linkedlifedata.com/resource/pubmed/chemical/SLC1A1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/SLC1A2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/SLC1A3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Symporters
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0002-953X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
158
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1393-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11532723-ATP-Binding Cassette Transporters,
pubmed-meshheading:11532723-Aged,
pubmed-meshheading:11532723-Amino Acid Transport System X-AG,
pubmed-meshheading:11532723-Carrier Proteins,
pubmed-meshheading:11532723-Excitatory Amino Acid Transporter 1,
pubmed-meshheading:11532723-Excitatory Amino Acid Transporter 2,
pubmed-meshheading:11532723-Excitatory Amino Acid Transporter 3,
pubmed-meshheading:11532723-Female,
pubmed-meshheading:11532723-Glutamate Plasma Membrane Transport Proteins,
pubmed-meshheading:11532723-Humans,
pubmed-meshheading:11532723-In Situ Hybridization,
pubmed-meshheading:11532723-Male,
pubmed-meshheading:11532723-Membrane Glycoproteins,
pubmed-meshheading:11532723-RNA, Messenger,
pubmed-meshheading:11532723-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:11532723-Receptors, Neurotransmitter,
pubmed-meshheading:11532723-Schizophrenia,
pubmed-meshheading:11532723-Symporters,
pubmed-meshheading:11532723-Thalamic Nuclei,
pubmed-meshheading:11532723-Thalamus,
pubmed-meshheading:11532723-Transcription, Genetic
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pubmed:year |
2001
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pubmed:articleTitle |
Expression of excitatory amino acid transporter transcripts in the thalamus of subjects with schizophrenia.
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pubmed:affiliation |
Department of Psychiatry/Mental Health Research Institute, University of Michigan Medical School, Ann Arbor 48109-0720, USA. smithrob@umich.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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