rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2001-9-4
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pubmed:abstractText |
Hereditary non-polyposis colorectal cancer is related to germline mutations of DNA mismatch repair genes MLH1 and MSH2, which result in microsatellite instability and loss of protein expression of the corresponding mutated gene in the tumour tissue.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MLH1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MSH2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MutS Homolog 2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0309-0167
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
250-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11532035-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:11532035-Adult,
pubmed-meshheading:11532035-Carrier Proteins,
pubmed-meshheading:11532035-Colorectal Neoplasms, Hereditary Nonpolyposis,
pubmed-meshheading:11532035-DNA-Binding Proteins,
pubmed-meshheading:11532035-Female,
pubmed-meshheading:11532035-Humans,
pubmed-meshheading:11532035-Immunohistochemistry,
pubmed-meshheading:11532035-Male,
pubmed-meshheading:11532035-Microsatellite Repeats,
pubmed-meshheading:11532035-Middle Aged,
pubmed-meshheading:11532035-MutS Homolog 2 Protein,
pubmed-meshheading:11532035-Neoplasm Proteins,
pubmed-meshheading:11532035-Nuclear Proteins,
pubmed-meshheading:11532035-Proto-Oncogene Proteins
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pubmed:year |
2001
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pubmed:articleTitle |
MLH1 and MSH2 protein immunohistochemistry is useful for detection of hereditary non-polyposis colorectal cancer in young patients.
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pubmed:affiliation |
Service d'Anatomie Pathologique, Centre Hospitalier Régional Universitaire Dupuytren, Limoges, France. ana.path@chu-limoges.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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