Linked Life Data

11531667

Source:http://linkedlifedata.com/resource/pubmed/id/11531667

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2001-9-4
pubmed:abstractText
This prospective randomised controlled study evaluated the effects of postoperative sedation with propofol and midazolam on pancreatic function. We studied 42 intensive care unit patients undergoing elective major surgery who were expected to be sedated postoperatively. Patients were randomly assigned to a propofol group (n = 21) or a midazolam group (n = 21). To assess pancreatic function, the following parameters were measured: pancreatitis-associated protein, amylase, lipase, cholesterol and triglyceride prior to start of sedation on the intensive care unit, 4 h after the sedation was started and at the first postoperative day. Patients in the propofol group received on average (SD) 1292 (430) mg propofol and were sedated for 9.03 (4.26) h. The midazolam group received 92 (36) mg midazolam and were sedated for 8.81 (4.68) h. Plasma cholesterol concentrations did not differ significantly between groups. Triglyceride plasma levels 4 h after the start of infusion were significantly higher in the propofol group (140 (54) mg.dl(-1)) than the midazolam-treated patients (81 (29) mg.dl(-1)), but were within normal limits. There were no significant differences between the two groups regarding amylase, lipase and pancreatitis-associated protein plasma concentrations at any time. No markers of pancreatic dysfunction were outside the normal range. We conclude that postoperative sedation with propofol induced a significant increase of serum triglyceride levels but that pancreatic function is unchanged with standard doses of propofol.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0003-2409
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
836-40
pubmed:dateRevised
2011-8-11
pubmed:meshHeading
pubmed-meshheading:11531667-Acute-Phase Proteins, pubmed-meshheading:11531667-Adult, pubmed-meshheading:11531667-Aged, pubmed-meshheading:11531667-Antigens, Neoplasm, pubmed-meshheading:11531667-Biological Markers, pubmed-meshheading:11531667-Cholesterol, pubmed-meshheading:11531667-Conscious Sedation, pubmed-meshheading:11531667-Female, pubmed-meshheading:11531667-Hemodynamics, pubmed-meshheading:11531667-Humans, pubmed-meshheading:11531667-Hypnotics and Sedatives, pubmed-meshheading:11531667-Intensive Care, pubmed-meshheading:11531667-Lectins, C-Type, pubmed-meshheading:11531667-Male, pubmed-meshheading:11531667-Midazolam, pubmed-meshheading:11531667-Middle Aged, pubmed-meshheading:11531667-Pancreas, pubmed-meshheading:11531667-Postoperative Care, pubmed-meshheading:11531667-Propofol, pubmed-meshheading:11531667-Prospective Studies, pubmed-meshheading:11531667-Triglycerides, pubmed-meshheading:11531667-Tumor Markers, Biological
pubmed:year
2001
pubmed:articleTitle
Effects of postoperative sedation with propofol and midazolam on pancreatic function assessed by pancreatitis-associated protein.
pubmed:affiliation
Department of Anaesthesiology and Intensive Care Medicine, Klinikum Ludwigshafen, Bremserstrasse 79, D-67063, Ludwigshafen, Germany.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Retracted Publication