Source:http://linkedlifedata.com/resource/pubmed/id/11531279
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2001-9-4
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| pubmed:abstractText |
The regulation of the metastatic process in epithelial ovarian cancer has not been well defined. Similar to other tumor types, the angiogenic phenotype in ovarian cancer strongly influences clinical outcome, suggesting that the acquisition of a pro-angiogenic environment is essential to the process of ovarian cancer proliferation and metastasis. Thrombospondin-1 (TSP-1) is a potent peptide shown in other tumor systems to be associated with angiogenesis and possibly regulated by p53, a gene which is mutated in as high as 50% of advanced ovarian cancers. The purpose of this study was to investigate TSP-1 expression in invasive epithelial ovarian cancer and to examine the relationship between TSP-1 expression and the degree of angiogenesis. In addition, we examined whether TSP-1 expression was associated with overexpression of p53.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0090-8258
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2001 Academic Press.
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| pubmed:issnType |
Print
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| pubmed:volume |
82
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
273-8
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| pubmed:dateRevised |
2006-4-24
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| pubmed:meshHeading |
pubmed-meshheading:11531279-Adult,
pubmed-meshheading:11531279-Aged,
pubmed-meshheading:11531279-Aged, 80 and over,
pubmed-meshheading:11531279-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:11531279-Carboplatin,
pubmed-meshheading:11531279-Cisplatin,
pubmed-meshheading:11531279-Epithelial Cells,
pubmed-meshheading:11531279-Female,
pubmed-meshheading:11531279-Gene Expression,
pubmed-meshheading:11531279-Genes, p53,
pubmed-meshheading:11531279-Humans,
pubmed-meshheading:11531279-Immunohistochemistry,
pubmed-meshheading:11531279-Middle Aged,
pubmed-meshheading:11531279-Multivariate Analysis,
pubmed-meshheading:11531279-Neoplasm Staging,
pubmed-meshheading:11531279-Neovascularization, Pathologic,
pubmed-meshheading:11531279-Ovarian Neoplasms,
pubmed-meshheading:11531279-Survival Rate,
pubmed-meshheading:11531279-Thrombospondin 1,
pubmed-meshheading:11531279-Tumor Suppressor Protein p53
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| pubmed:year |
2001
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| pubmed:articleTitle |
Thrombospondin-1 expression in epithelial ovarian carcinoma: association with p53 status, tumor angiogenesis, and survival in platinum-treated patients.
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| pubmed:affiliation |
Division of Gynecologic Oncology, Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, North Carolina 27710, USA.
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| pubmed:publicationType |
Journal Article
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