Source:http://linkedlifedata.com/resource/pubmed/id/11529355
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2001-8-31
|
| pubmed:abstractText |
A multicenter randomized, double blind, placebo-controlled clinical trial was conducted to evaluate the effectiveness of a short course of oral zidovudine (ZDV) treatment in HIV-1 infected pregnant women, starting at 38 weeks of gestation plus ZDV infusion during labor until delivery, to reduce HIV-1 vertical transmission in non-breast fed infants. One hundred and eighty two asymptomatic antiretroviral naïve HIV-1 infected pregnant women were enrolled. Each patient was randomly allocated into either the ZDV or placebo group. The ZDV group received 250 mg ZDV orally twice a day initiated at 38 weeks' gestation until the onset of labor. During the intrapartum period, ZDV infusion at the rate of 2 mg/kg was administered within the first hour and then continuously infused at the rate of 1 mg/kg/h until delivery. The placebo group received an identical capsule during pregnancy and normal saline infusion during labor until delivery. HIV-1 transmission was documented by nested polymerase chain reaction in infants at birth and at 1, 3 and, 6 months of age. The estimated HIV-1 vertical transmission rate was 14.9 per cent (95% CI = 11.1 to 18.7) and 16.3 per cent (95% CI = 12.3 to 20.9) in ZDV and placebo group, respectively (p > 0.05). The short course ZDV in antiretroviral naïve pregnant women initiated at 38 weeks' gestation plus intrapartum ZDV infusion without treatment in the infants was not effective to prevent HIV-1 vertical transmission.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0125-2208
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| pubmed:author |
pubmed-author:ChaithongwongwatthanaSS,
pubmed-author:ChantheptaewanNN,
pubmed-author:ChulasugondhaPP,
pubmed-author:HanwanichMM,
pubmed-author:HawanonPP,
pubmed-author:KongsinPP,
pubmed-author:LimpongsanurakSS,
pubmed-author:PhanuphakPP,
pubmed-author:RuxrungthamKK,
pubmed-author:TarounotaiUU,
pubmed-author:ThaithumyanonPP,
pubmed-author:ThisyakornUU,
pubmed-author:TriratwerapongTT,
pubmed-author:UbolyamSS,
pubmed-author:VirutamasenPP
|
| pubmed:issnType |
Print
|
| pubmed:volume |
84 Suppl 1
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
S338-45
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:11529355-Adolescent,
pubmed-meshheading:11529355-Adult,
pubmed-meshheading:11529355-Anti-HIV Agents,
pubmed-meshheading:11529355-Chi-Square Distribution,
pubmed-meshheading:11529355-Double-Blind Method,
pubmed-meshheading:11529355-Drug Administration Schedule,
pubmed-meshheading:11529355-Female,
pubmed-meshheading:11529355-Gestational Age,
pubmed-meshheading:11529355-HIV Infections,
pubmed-meshheading:11529355-HIV Seropositivity,
pubmed-meshheading:11529355-HIV-1,
pubmed-meshheading:11529355-Humans,
pubmed-meshheading:11529355-Infectious Disease Transmission, Vertical,
pubmed-meshheading:11529355-Pregnancy,
pubmed-meshheading:11529355-Pregnancy Complications, Infectious,
pubmed-meshheading:11529355-Pregnancy Outcome,
pubmed-meshheading:11529355-Prognosis,
pubmed-meshheading:11529355-Statistics, Nonparametric,
pubmed-meshheading:11529355-Treatment Outcome,
pubmed-meshheading:11529355-Zidovudine
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Short course zidovudine maternal treatment in HIV-1 vertical transmission: randomized controlled multicenter trial.
|
| pubmed:affiliation |
Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
|