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pubmed-article:11527740pubmed:abstractTextThe synthesis and biological activities of a series of new 1beta-methylcarbapenems 1a-h having heteroaromatic thioether moiety at C-5 position of pyrrolidine were described. Among these compounds, 1,2,3-thiadiazole derivative 1h showed the most potent antibacterial activity and advanced pharmacokinetics in comparison with meropenem.lld:pubmed
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pubmed-article:11527740pubmed:articleTitleSynthesis and biological properties of new 1beta-methylcarbapenems containing heteroaromatic thioether moiety.lld:pubmed
pubmed-article:11527740pubmed:affiliationMedicinal Chemistry Research Center, Korea Institute of Science and Technology, Seoul 130-650, South Korea.lld:pubmed
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