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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2001-8-30
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pubmed:abstractText |
1-Aryl-3-carboxamido-5-alkylpyrazoles were prepared based on a hit found in high-throughput screening of our corporate compound library in an assay measuring affinity for the human neuropeptide Y5 receptor. 1-(3-Trifluoromethylphenyl)-3-[N-(5-quinolinyl)carboxamido]-5-methylpyrazole (31) bound to the human neuropeptide Y5 receptor with a 80 nM IC(50 )and was shown to inhibit cumulative food consumption 43.2% 2-6 h after ip dosing in a fasting-induced feeding model in rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2287-90
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:11527716-Animals,
pubmed-meshheading:11527716-Drug Evaluation, Preclinical,
pubmed-meshheading:11527716-Eating,
pubmed-meshheading:11527716-Fasting,
pubmed-meshheading:11527716-Humans,
pubmed-meshheading:11527716-Inhibitory Concentration 50,
pubmed-meshheading:11527716-Isoquinolines,
pubmed-meshheading:11527716-Ligands,
pubmed-meshheading:11527716-Male,
pubmed-meshheading:11527716-Pyrazoles,
pubmed-meshheading:11527716-Rats,
pubmed-meshheading:11527716-Rats, Long-Evans,
pubmed-meshheading:11527716-Receptors, Neuropeptide Y,
pubmed-meshheading:11527716-Structure-Activity Relationship
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pubmed:year |
2001
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pubmed:articleTitle |
Pyrazolecarboxamide human neuropeptide Y5 receptor ligands with in vivo antifeedant activity.
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pubmed:affiliation |
Drug Discovery Division, The R. W. Johnson Pharmaceutical Research Institute, Welsh and McKean Roads, Spring House, PA 19477, USA. ckordik@pruis.jnj.com
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pubmed:publicationType |
Journal Article
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