Source:http://linkedlifedata.com/resource/pubmed/id/11527715
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
17
|
| pubmed:dateCreated |
2001-8-30
|
| pubmed:abstractText |
1,3-Disubstituted-5-aminopyrazoles were prepared based on a lead compound found through high-throughput screening of our corporate compound library in an assay measuring affinity for the human neuropeptide Y5 receptor. The target compounds were prepared by cyclization of alpha-cyanoketones with appropriate hydrazines, followed by reduction and coupling to various sulfonamido-carboxylic acids. Several of these arylpyrazoles (e.g., 19 and 45) displayed high affinity for the human NPY Y5 receptor (<20nM IC(50)s).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
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| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
3
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2283-6
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11527715-Binding, Competitive,
pubmed-meshheading:11527715-Cell Line,
pubmed-meshheading:11527715-Drug Design,
pubmed-meshheading:11527715-Drug Evaluation, Preclinical,
pubmed-meshheading:11527715-Humans,
pubmed-meshheading:11527715-Inhibitory Concentration 50,
pubmed-meshheading:11527715-Pyrazoles,
pubmed-meshheading:11527715-Receptors, Neuropeptide Y,
pubmed-meshheading:11527715-Structure-Activity Relationship,
pubmed-meshheading:11527715-Sulfonamides
|
| pubmed:year |
2001
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| pubmed:articleTitle |
Aminopyrazoles with high affinity for the human neuropeptide Y5 receptor.
|
| pubmed:affiliation |
Drug Discovery Division, The R. W. Johnson Pharmaceutical Research Institute, Welsh and McKean Roads, Spring House, PA 19477, USA. ckordik@prius.jnj.com
|
| pubmed:publicationType |
Journal Article
|