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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2001-8-30
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pubmed:abstractText |
The mechanism of bacimethrin (2) toxicity has been determined. This compound is converted to 2'-methoxy-thiamin pyrophosphate (10) by the thiamin biosynthetic enzymes. Of the seven thiamin pyrophosphate utilizing enzymes in Escherichia coli, 2'-methoxy-thiamin pyrophosphate inhibits alpha-ketoglutarate dehydrogenase, transketolase, and deoxy-D-xylulose-5-phosphate synthase. Bacimethrin does not cause repression of the genes coding for the thiamin biosynthetic enzymes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-succinyl-6-hydroxy-2,4-cyclohexadi...,
http://linkedlifedata.com/resource/pubmed/chemical/Antimetabolites,
http://linkedlifedata.com/resource/pubmed/chemical/Enzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Ketoglutarate Dehydrogenase Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Oxo-Acid-Lyases,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphotransferases (Alcohol Group...,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/Thiamine,
http://linkedlifedata.com/resource/pubmed/chemical/Thiamine Pyrophosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Transketolase,
http://linkedlifedata.com/resource/pubmed/chemical/bacimethrin,
http://linkedlifedata.com/resource/pubmed/chemical/hydroxymethylpyrimidine kinase
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2245-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11527707-Antimetabolites,
pubmed-meshheading:11527707-Enzymes,
pubmed-meshheading:11527707-Escherichia coli,
pubmed-meshheading:11527707-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:11527707-Ketoglutarate Dehydrogenase Complex,
pubmed-meshheading:11527707-Multigene Family,
pubmed-meshheading:11527707-Oxo-Acid-Lyases,
pubmed-meshheading:11527707-Phosphotransferases (Alcohol Group Acceptor),
pubmed-meshheading:11527707-Pyrimidines,
pubmed-meshheading:11527707-Substrate Specificity,
pubmed-meshheading:11527707-Thiamine,
pubmed-meshheading:11527707-Thiamine Pyrophosphate,
pubmed-meshheading:11527707-Transketolase
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pubmed:year |
2001
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pubmed:articleTitle |
The mechanism of action of bacimethrin, a naturally occurring thiamin antimetabolite.
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pubmed:affiliation |
Department of Chemistry and Chemical Biology, Cornell University, Baker Laboratory, Ithaca, NY 14853, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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