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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2001-8-30
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pubmed:abstractText |
A novel inhibitor of voltage-gated K(+) channels has been purified to homogeneity from the venom of the black scorpion Orthochirus scrobiculosus. This toxin, named OsK2, has been characterized as a 28-residue peptide, containing six conserved cysteine residues and was shown to be a potent and selective blocker of Kv1.2 channels (K(d) = 97 nM). OsK2 is the second member of the 13th subfamily of short-chain K(+) channel-blocking peptides known thus far and is therefore called alpha-KTx 13.2.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
286
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
841-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11527374-Amino Acid Sequence,
pubmed-meshheading:11527374-Animals,
pubmed-meshheading:11527374-Chromatography,
pubmed-meshheading:11527374-Chromatography, Gel,
pubmed-meshheading:11527374-Chromatography, High Pressure Liquid,
pubmed-meshheading:11527374-Cysteine,
pubmed-meshheading:11527374-DNA, Complementary,
pubmed-meshheading:11527374-Diptera,
pubmed-meshheading:11527374-Dose-Response Relationship, Drug,
pubmed-meshheading:11527374-Electrophysiology,
pubmed-meshheading:11527374-Grasshoppers,
pubmed-meshheading:11527374-Kinetics,
pubmed-meshheading:11527374-Kv1.2 Potassium Channel,
pubmed-meshheading:11527374-Mass Spectrometry,
pubmed-meshheading:11527374-Molecular Sequence Data,
pubmed-meshheading:11527374-Muscles,
pubmed-meshheading:11527374-Neurons,
pubmed-meshheading:11527374-Oocytes,
pubmed-meshheading:11527374-Peptides,
pubmed-meshheading:11527374-Plasmids,
pubmed-meshheading:11527374-Potassium Channel Blockers,
pubmed-meshheading:11527374-Potassium Channels,
pubmed-meshheading:11527374-Potassium Channels, Voltage-Gated,
pubmed-meshheading:11527374-Scorpion Venoms,
pubmed-meshheading:11527374-Scorpions,
pubmed-meshheading:11527374-Sequence Analysis, Protein,
pubmed-meshheading:11527374-Sequence Homology, Amino Acid,
pubmed-meshheading:11527374-Time Factors
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pubmed:year |
2001
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pubmed:articleTitle |
OsK2, a new selective inhibitor of Kv1.2 potassium channels purified from the venom of the scorpion Orthochirus scrobiculosus.
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pubmed:affiliation |
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya, 16/10, Moscow, 117997, GSP, Russia. dudinaee@azt.cardio.ru
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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