Linked Life Data

11526829

Source:http://linkedlifedata.com/resource/pubmed/id/11526829

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-8-30
pubmed:abstractText
Isolated and cleaned giant axons of Loligo pealii were internally perfused with solutions containing cesium sulfate and potassium fluoride. Membrane currents obtained as a function of clamped membrane potentials indicated a severe depression of the delayed outward current component normally attributed to potassium ion movement. Steady-state currents showed a negative slope in the potential range from -45 to -5 mv which corresponded to the negative slope for the peak sodium current relation vs. membrane potential which suggested long duration sodium currents. Using sodium-free sea water externally, sodium currents were separated from total currents and these persisted for longer times than normal. This result suggested that internal cesium ion delays the sodium conductance turnoff. The separated nonsodium currents showed an abnormal rectification as compared with those predicted by the independence principle, such that while potassium permeability appeared normal at the resting potential, its value decreased progressively with increasing depolarization.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11526829-11526828, http://linkedlifedata.com/resource/pubmed/commentcorrection/11526829-12991237, http://linkedlifedata.com/resource/pubmed/commentcorrection/11526829-13969165, http://linkedlifedata.com/resource/pubmed/commentcorrection/11526829-14013543, http://linkedlifedata.com/resource/pubmed/commentcorrection/11526829-14232131, http://linkedlifedata.com/resource/pubmed/commentcorrection/11526829-14245457, http://linkedlifedata.com/resource/pubmed/commentcorrection/11526829-14245458, http://linkedlifedata.com/resource/pubmed/commentcorrection/11526829-14448232, http://linkedlifedata.com/resource/pubmed/commentcorrection/11526829-14946713, http://linkedlifedata.com/resource/pubmed/commentcorrection/11526829-5880363, http://linkedlifedata.com/resource/pubmed/commentcorrection/11526829-5909788
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-1295
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
279-93
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1966
pubmed:articleTitle
Voltage clamp studies on the effect of internal cesium ion on sodium and potassium currents in the squid giant axon.
pubmed:affiliation
Department of Physiology, School of Medicine, University of Maryland, Baltimore, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.