| pubmed-article:11526476 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11526476 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:11526476 | lifeskim:mentions | umls-concept:C1321894 | lld:lifeskim |
| pubmed-article:11526476 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:11526476 | lifeskim:mentions | umls-concept:C0597611 | lld:lifeskim |
| pubmed-article:11526476 | lifeskim:mentions | umls-concept:C0040624 | lld:lifeskim |
| pubmed-article:11526476 | pubmed:issue | 36 | lld:pubmed |
| pubmed-article:11526476 | pubmed:dateCreated | 2001-8-29 | lld:pubmed |
| pubmed-article:11526476 | pubmed:abstractText | Multiple endocrine neoplasia type 1 is an autosomal dominant tumor syndrome. Manifestations include neoplasms of the parathyroid glands, enteropancreatic neuroendocrine cells, and the anterior pituitary gland. The MEN1 tumor suppressor gene encodes menin, a 610 amino acid nuclear protein without sequence homology to other proteins. To elucidate menin function, we used immunoprecipitation to identify interacting proteins. The NF-kappaB proteins p50, p52 and p65 were found to interact specifically and directly with menin in vitro and in vivo. The region of NF-kappaB proteins sufficient for binding to menin is the N-terminus. Furthermore, amino acids 305-381 of menin are essential for this binding. Menin represses p65-mediated transcriptional activation on NF-kappaB sites in a dose-dependent and specific manner. Also, PMA (phorbol 12-myristate 13-acetate)-stimulated NF-kappaB activation is suppressed by menin. These observations suggest that menin's ability to interact with NF-kappaB proteins and its modulation of NF-kappaB transactivation contribute to menin's tumor suppressor function. | lld:pubmed |
| pubmed-article:11526476 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11526476 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11526476 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11526476 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11526476 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:11526476 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:11526476 | pubmed:author | pubmed-author:AgarwalS KSK | lld:pubmed |
| pubmed-article:11526476 | pubmed:author | pubmed-author:MarxS JSJ | lld:pubmed |
| pubmed-article:11526476 | pubmed:author | pubmed-author:SpiegelA MAM | lld:pubmed |
| pubmed-article:11526476 | pubmed:author | pubmed-author:BurnsA LAL | lld:pubmed |
| pubmed-article:11526476 | pubmed:author | pubmed-author:CollinsF SFS | lld:pubmed |
| pubmed-article:11526476 | pubmed:author | pubmed-author:HeppnerCC | lld:pubmed |
| pubmed-article:11526476 | pubmed:author | pubmed-author:KesterMM | lld:pubmed |
| pubmed-article:11526476 | pubmed:author | pubmed-author:GuruS CSC | lld:pubmed |
| pubmed-article:11526476 | pubmed:author | pubmed-author:Chandrasekhar... | lld:pubmed |
| pubmed-article:11526476 | pubmed:author | pubmed-author:BilimoriaK... | lld:pubmed |
| pubmed-article:11526476 | pubmed:author | pubmed-author:WhittyL JLJ | lld:pubmed |
| pubmed-article:11526476 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11526476 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:11526476 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:11526476 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11526476 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11526476 | pubmed:pagination | 4917-25 | lld:pubmed |
| pubmed-article:11526476 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:11526476 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11526476 | pubmed:articleTitle | The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation. | lld:pubmed |
| pubmed-article:11526476 | pubmed:affiliation | Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA. | lld:pubmed |
| pubmed-article:11526476 | pubmed:publicationType | Journal Article | lld:pubmed |
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