| pubmed-article:11526402 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11526402 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:11526402 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:11526402 | lifeskim:mentions | umls-concept:C1711368 | lld:lifeskim |
| pubmed-article:11526402 | lifeskim:mentions | umls-concept:C1510470 | lld:lifeskim |
| pubmed-article:11526402 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:11526402 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:11526402 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:11526402 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:11526402 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:11526402 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:11526402 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:11526402 | pubmed:dateCreated | 2001-8-29 | lld:pubmed |
| pubmed-article:11526402 | pubmed:abstractText | Lsc (the murine homolog of human p115 Rho GEF) is a member of the Dbl-homology family of GTP exchange factors and is a specific activator of Rho. Lsc is activated by the G alpha(13) subunit of heterotrimeric G proteins and contains a regulator of G protein signaling domain that downmodulates G alpha(12) and G alpha(13). Lsc is expressed primarily in the hematopoietic system and links the activation of G alpha(12) and G alpha(13)-coupled receptors to actin polymerization in B and T cells. Lsc is essential for marginal zone B (MZB) cell homeostasis and for the generation of immune responses. Although Lsc-deficient lymphocytes show reduced basal motility, MZB cells show enhanced migration after serum activation. Thus, Lsc is a critical regulator of MZB cells and immune functions. | lld:pubmed |
| pubmed-article:11526402 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11526402 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11526402 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11526402 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11526402 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11526402 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:11526402 | pubmed:issn | 1529-2908 | lld:pubmed |
| pubmed-article:11526402 | pubmed:author | pubmed-author:PötzelTT | lld:pubmed |
| pubmed-article:11526402 | pubmed:author | pubmed-author:FischerK DKD | lld:pubmed |
| pubmed-article:11526402 | pubmed:author | pubmed-author:PfefferKK | lld:pubmed |
| pubmed-article:11526402 | pubmed:author | pubmed-author:SakiTT | lld:pubmed |
| pubmed-article:11526402 | pubmed:author | pubmed-author:TedfordKK | lld:pubmed |
| pubmed-article:11526402 | pubmed:author | pubmed-author:GirkontaiteII | lld:pubmed |
| pubmed-article:11526402 | pubmed:author | pubmed-author:MissyKK | lld:pubmed |
| pubmed-article:11526402 | pubmed:author | pubmed-author:HarenbergAA | lld:pubmed |
| pubmed-article:11526402 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11526402 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:11526402 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11526402 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11526402 | pubmed:pagination | 855-62 | lld:pubmed |
| pubmed-article:11526402 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11526402 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11526402 | pubmed:articleTitle | Lsc is required for marginal zone B cells, regulation of lymphocyte motility and immune responses. | lld:pubmed |
| pubmed-article:11526402 | pubmed:affiliation | Abteilung Physiologische Chemie, Universität Ulm, Albert-Einstein-Allee 11, D-89069 Ulm, Germany. | lld:pubmed |
| pubmed-article:11526402 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11526402 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:16801 | entrezgene:pubmed | pubmed-article:11526402 | lld:entrezgene |
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