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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2001-8-29
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pubmed:abstractText |
Lsc (the murine homolog of human p115 Rho GEF) is a member of the Dbl-homology family of GTP exchange factors and is a specific activator of Rho. Lsc is activated by the G alpha(13) subunit of heterotrimeric G proteins and contains a regulator of G protein signaling domain that downmodulates G alpha(12) and G alpha(13). Lsc is expressed primarily in the hematopoietic system and links the activation of G alpha(12) and G alpha(13)-coupled receptors to actin polymerization in B and T cells. Lsc is essential for marginal zone B (MZB) cell homeostasis and for the generation of immune responses. Although Lsc-deficient lymphocytes show reduced basal motility, MZB cells show enhanced migration after serum activation. Thus, Lsc is a critical regulator of MZB cells and immune functions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1529-2908
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
855-62
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11526402-Animals,
pubmed-meshheading:11526402-B-Lymphocytes,
pubmed-meshheading:11526402-Cells, Cultured,
pubmed-meshheading:11526402-Chemotaxis, Leukocyte,
pubmed-meshheading:11526402-DNA-Binding Proteins,
pubmed-meshheading:11526402-GTP-Binding Protein alpha Subunits, G12-G13,
pubmed-meshheading:11526402-Gene Targeting,
pubmed-meshheading:11526402-Guanine Nucleotide Exchange Factors,
pubmed-meshheading:11526402-Hematopoietic Stem Cells,
pubmed-meshheading:11526402-Heterotrimeric GTP-Binding Proteins,
pubmed-meshheading:11526402-Immunoglobulins,
pubmed-meshheading:11526402-Lymphocyte Activation,
pubmed-meshheading:11526402-Lymphocyte Subsets,
pubmed-meshheading:11526402-Lymphoid Tissue,
pubmed-meshheading:11526402-Mice,
pubmed-meshheading:11526402-Mice, Knockout,
pubmed-meshheading:11526402-Platelet Aggregation,
pubmed-meshheading:11526402-Proto-Oncogene Proteins,
pubmed-meshheading:11526402-Recombination, Genetic,
pubmed-meshheading:11526402-Tissue Distribution
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pubmed:year |
2001
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pubmed:articleTitle |
Lsc is required for marginal zone B cells, regulation of lymphocyte motility and immune responses.
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pubmed:affiliation |
Abteilung Physiologische Chemie, Universität Ulm, Albert-Einstein-Allee 11, D-89069 Ulm, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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