Source:http://linkedlifedata.com/resource/pubmed/id/11525774
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
2001-8-29
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pubmed:abstractText |
Exposure of rats to a single session of foot shocks sensitizes behavioral responses to novel stimuli. There is evidence that metabotropic glutamate (mGlu) receptors play a role in sensitization processes. In the present study, we investigated the role of mGlu(2/3) receptors in the long-term (14 days) increase in defensive withdrawal behavior after a single session of foot shocks. Exposure to foot shocks increased defensive withdrawal behavior. The mGlu(2/3) receptor agonist LY354740 ((1S,2S,5R,6S)-(+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 0.1 mg/kg, i.p.) normalized the increased latency and the decreased time in the light of the preshocked rats. We conclude that activation of mGlu(2/3) receptors attenuates the foot shock-induced expression of behavioral sensitization.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0014-2999
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
426
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
77-80
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11525774-Animals,
pubmed-meshheading:11525774-Behavior, Animal,
pubmed-meshheading:11525774-Bicyclo Compounds,
pubmed-meshheading:11525774-Dose-Response Relationship, Drug,
pubmed-meshheading:11525774-Electroshock,
pubmed-meshheading:11525774-Excitatory Amino Acid Agonists,
pubmed-meshheading:11525774-Foot,
pubmed-meshheading:11525774-Male,
pubmed-meshheading:11525774-Rats,
pubmed-meshheading:11525774-Rats, Wistar,
pubmed-meshheading:11525774-Time Factors
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pubmed:year |
2001
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pubmed:articleTitle |
LY354740 attenuates the expression of long-term behavioral sensitization induced by a single session of foot shocks.
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pubmed:affiliation |
Division of Pharmacology and Anatomy, Rudolf Magnus Institute for Neurosciences, University Medical Center Utrecht, P.O. Box 85060, 3508 AB, Utrecht, The Netherlands. A.W.Bruijnzeel@med.uu.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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