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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2001-8-29
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pubmed:abstractText |
We incorporate a representation of Plasmodium falciparum recombination within a discrete-event model of malaria transmission. We simulate the introduction of a new parasite genotype into a human population in which another genotype has reached equilibrium prevalence and compare the emergence and persistence of the novel recombinant forms under differing cross-reactivity relationships between the genotypes. Cross-reactivity between the parental (initial and introduced) genotypes reduces the frequency of appearance of recombinants within three years of introduction from 100% to 14%, and delays their appearance by more than a year, on average. Cross-reactivity between parental and recombinant genotypes reduces the frequency of appearance to 36% and increases the probability of recombinant extinction following appearance from 0% to 83%. When a recombinant is cross-reactive with its parental types, its probability of extinction is influenced by cross-reactivity between the parental types in the opposite manner; that is, its probability of extinction after appearance decreases. Frequencies of P. falciparum outcrossing are mediated by frequencies of mixed-genotype infections in the host population, which are in turn mediated by the structure of cross-reactivity between parasite genotypes. The three leading hypotheses about how meiosis relates to oocyst production lead to quantitative, but no qualitative, differences in these results.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-10207356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-10326095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-10339390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-10340323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-10599074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-10674079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-10717738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-10804031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-10893865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-11018154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-15275362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-1635032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-1775167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-3906103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-6006329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-8651363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-8893528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-9180605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-9220675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-9236275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-9299316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-9469800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-9576766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-9584096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-9735270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-9749648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-9836305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11525454-9920333
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0014-3820
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1299-307
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pubmed:dateRevised |
2011-9-19
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pubmed:meshHeading |
pubmed-meshheading:11525454-Alleles,
pubmed-meshheading:11525454-Animals,
pubmed-meshheading:11525454-Cross Reactions,
pubmed-meshheading:11525454-Culicidae,
pubmed-meshheading:11525454-Evolution, Molecular,
pubmed-meshheading:11525454-Female,
pubmed-meshheading:11525454-Genotype,
pubmed-meshheading:11525454-Humans,
pubmed-meshheading:11525454-Malaria, Falciparum,
pubmed-meshheading:11525454-Meiosis,
pubmed-meshheading:11525454-Models, Biological,
pubmed-meshheading:11525454-Plasmodium falciparum,
pubmed-meshheading:11525454-Recombination, Genetic,
pubmed-meshheading:11525454-Virulence
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pubmed:year |
2001
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pubmed:articleTitle |
Meiotic recombination, cross-reactivity, and persistence in Plasmodium falciparum.
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pubmed:affiliation |
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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