Source:http://linkedlifedata.com/resource/pubmed/id/11524112
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2001-8-28
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pubmed:abstractText |
Hypa A, a novel macrocyclic polypeptide containing 30 amino acid residues, has been isolated from the n-butanol extract of the Argentine plant Hybanthus parviflorus. The sequence, cyclo-(SCVYIPCTITALLGCSCKNKVCYNGIPCAE), was determined by automated Edman degradation, quantitative amino acid analysis and nanospray MS/MS(2). Three intramolecular disulfide bridges stabilize the cyclic peptide backbone of hypa A. Using these structural features to classify the peptide as a cyclotide, we extended the distribution of that substance class to a new genus, and now propose a uniform nomenclature for cyclotides.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0031-9422
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
47-51
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11524112-Amino Acid Sequence,
pubmed-meshheading:11524112-Argentina,
pubmed-meshheading:11524112-Disulfides,
pubmed-meshheading:11524112-Drug Stability,
pubmed-meshheading:11524112-Mass Spectrometry,
pubmed-meshheading:11524112-Molecular Sequence Data,
pubmed-meshheading:11524112-Peptides, Cyclic,
pubmed-meshheading:11524112-Rosaceae,
pubmed-meshheading:11524112-Terminology as Topic
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pubmed:year |
2001
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pubmed:articleTitle |
First cyclotide from Hybanthus (Violaceae).
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pubmed:affiliation |
Instituto de Química y Metabolismo del Fármaco (IQUIMEFA) (UBA-CONICET), Cátedra de Farmacognosia, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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