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rdf:type |
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lifeskim:mentions |
umls-concept:C0205460,
umls-concept:C0332281,
umls-concept:C0871261,
umls-concept:C1335238,
umls-concept:C1512505,
umls-concept:C1521805,
umls-concept:C1704240,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1879547,
umls-concept:C2911692
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pubmed:issue |
5
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pubmed:dateCreated |
2001-8-28
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pubmed:abstractText |
The nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) has become a potential target for the prevention and treatment of breast cancer. However, recent in vitro and in vivo studies have raised the question of whether activation of PPARgamma leads to the promotion or reduction of tumor formation. Studies using several cancer cell lines, animal models, and a variety of PPARgamma agonists have shown discordant results, including changes in cellular proliferation, differentiation, and apoptosis of cancer cells and tumors.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1081-5589
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
413-20
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11523697-Apoptosis,
pubmed-meshheading:11523697-Breast Neoplasms,
pubmed-meshheading:11523697-Cell Cycle,
pubmed-meshheading:11523697-Cell Differentiation,
pubmed-meshheading:11523697-Cell Division,
pubmed-meshheading:11523697-Chromans,
pubmed-meshheading:11523697-Female,
pubmed-meshheading:11523697-Humans,
pubmed-meshheading:11523697-Prostaglandin D2,
pubmed-meshheading:11523697-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:11523697-Thiazoles,
pubmed-meshheading:11523697-Thiazolidinediones,
pubmed-meshheading:11523697-Transcription Factors,
pubmed-meshheading:11523697-Transcriptional Activation,
pubmed-meshheading:11523697-Tumor Cells, Cultured
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pubmed:year |
2001
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pubmed:articleTitle |
Magnitude of peroxisome proliferator-activated receptor-gamma activation is associated with important and seemingly opposite biological responses in breast cancer cells.
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pubmed:affiliation |
Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1042, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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