| pubmed-article:11522597 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11522597 | lifeskim:mentions | umls-concept:C0013227 | lld:lifeskim |
| pubmed-article:11522597 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11522597 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11522597 | lifeskim:mentions | umls-concept:C0079784 | lld:lifeskim |
| pubmed-article:11522597 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:11522597 | lifeskim:mentions | umls-concept:C0018183 | lld:lifeskim |
| pubmed-article:11522597 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:11522597 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:11522597 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:11522597 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:11522597 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:11522597 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:11522597 | lifeskim:mentions | umls-concept:C0439596 | lld:lifeskim |
| pubmed-article:11522597 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:11522597 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11522597 | pubmed:dateCreated | 2001-8-27 | lld:pubmed |
| pubmed-article:11522597 | pubmed:abstractText | 1. Granulocyte/macrophage colony-stimulating factor (GM-CSF) is a pro-inflammatory cytokine secreted by cells of the monocyte/macrophage lineage and has been implicated in the pathogenesis of bronchitis and asthma. 2. In the present study we have evaluated the effect of several cyclic AMP-elevating agents on lipopolysaccharide (LPS)-induced GM-CSF release from human monocytes and the extent to which the anti-inflammatory cytokine, interleukin (IL)-10, is involved. 3. LPS evoked a concentration-dependent generation of GM-CSF from human monocytes that was inhibited, at the mRNA and protein level, by 8-Br-cyclic AMP, cholera toxin, prostaglandin E2 (PGE2) and a number of structurally dissimilar phosphodiesterase (PDE) 4 inhibitors. 4. Pre-treatment of monocytes with a concentration of an anti-IL-10 monoclonal antibody that abolished the inhibitory action of a maximally effective concentration of exogenous human recombinant IL-10, significantly augmented LPS-induced GM-CSF generation. This effect was associated with a parallel upwards displacement of the concentration-response curves that described the inhibition of GM-CSF by PGE2, 8-Br-cyclic AMP and the PDE4 inhibitor, rolipram, without significantly changing the potency of any drug. Consequently, the maximum percentage inhibition of GM-CSF release was reduced. Further experiments established that the reduction in the maximum inhibition of GM-CSF release seen in anti-IL-10-treated cells was not due to functional antagonism as rolipram, PGE2 and 8-Br-cyclic AMP were equi-effective at all concentrations of LPS studied. 5. These data indicate that cyclic AMP-elevating drugs attenuate the elaboration of GM-CSF from LPS-stimulated human monocytes by a mechanism that is not mediated via IL-10. Suppression of GM-CSF from monocytes may explain, at least in part, the efficacy of PDE4 inhibitors in clinical trials of chronic obstructive pulmonary disease. | lld:pubmed |
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| pubmed-article:11522597 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11522597 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11522597 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11522597 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:11522597 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:11522597 | pubmed:author | pubmed-author:GiembyczM AMA | lld:pubmed |
| pubmed-article:11522597 | pubmed:author | pubmed-author:SeldonP MPM | lld:pubmed |
| pubmed-article:11522597 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11522597 | pubmed:volume | 134 | lld:pubmed |
| pubmed-article:11522597 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11522597 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11522597 | pubmed:pagination | 58-67 | lld:pubmed |
| pubmed-article:11522597 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11522597 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11522597 | pubmed:articleTitle | Suppression of granulocyte/macrophage colony-stimulating factor release from human monocytes by cyclic AMP-elevating drugs: role of interleukin-10. | lld:pubmed |
