Source:http://linkedlifedata.com/resource/pubmed/id/11521219
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
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| pubmed:dateCreated |
2001-8-24
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| pubmed:abstractText |
To investigate the possible roles of p27(KIP1) and p21(WAF1/CIP1), inhibitors of cyclin-dependent kinases, in hepatocellular carcinoma (HCC), we examined p27(KIP1) and p21(WAF1/CIP1) expression in primary HCC with immunohistochemistry and Northern blot hybridization and correlated the results with clinicopathologic features and survival. With immunohistochemistry, positive staining for p27(KIP1) and p21(WAF1/CIP1) protein was found in 54.3% and 63.8% of HCCs, respectively. Both p27(KIP1) and p21(WAF1/CIP1) scores of the tumors were significantly higher than those of the corresponding nontumorous livers (P <.0001 and.009, respectively). Higher levels of p27(KIP1) were associated with a lower incidence of direct liver invasion (P =.021) and, less significantly, with a low incidence of multiple tumor nodules (P =.056). Patients whose tumors had higher p27(KIP1) protein scores had longer disease-free survival (P =.011). For p21(WAF1/CIP1), in contrast to the overexpression of the p21(WAF1/CIP1) protein in HCC, the relative amounts of p21(WAF1/CIP1) messenger RNA (mRNA) in the tumors were found to be reduced compared with those of the nontumorous livers (P =.039). In conclusion, p27(KIP1) and p21(WAF1/CIP1) proteins were frequently overexpressed in HCC. Longer disease-free survival rates were seen in patients whose tumors had higher p27(KIP1) expression. The accumulation of p21(WAF1/CIP) protein in the presence of a reduced mRNA level suggests probable posttranslational protein stabilization, and the reduced transcription of p21(WAF1/CIP) may represent a form of dysfunction of cyclin-dependent kinase inhibitor involved in hepatocarcinogenesis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CDKN1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0046-8177
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
32
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
778-84
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:11521219-Adult,
pubmed-meshheading:11521219-Aged,
pubmed-meshheading:11521219-Blotting, Northern,
pubmed-meshheading:11521219-Carcinoma, Hepatocellular,
pubmed-meshheading:11521219-Cell Cycle Proteins,
pubmed-meshheading:11521219-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:11521219-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:11521219-Cyclin-Dependent Kinases,
pubmed-meshheading:11521219-Cyclins,
pubmed-meshheading:11521219-Disease-Free Survival,
pubmed-meshheading:11521219-Female,
pubmed-meshheading:11521219-Humans,
pubmed-meshheading:11521219-Immunoenzyme Techniques,
pubmed-meshheading:11521219-Liver Neoplasms,
pubmed-meshheading:11521219-Male,
pubmed-meshheading:11521219-Middle Aged,
pubmed-meshheading:11521219-Neoplasm Invasiveness,
pubmed-meshheading:11521219-RNA, Messenger,
pubmed-meshheading:11521219-RNA, Neoplasm,
pubmed-meshheading:11521219-Survival Rate,
pubmed-meshheading:11521219-Tumor Suppressor Proteins
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| pubmed:year |
2001
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| pubmed:articleTitle |
Expression of p27(KIP1) and p21(WAF1/CIP1) in primary hepatocellular carcinoma: clinicopathologic correlation and survival analysis.
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| pubmed:affiliation |
Department of Pathology, the University of Hong Kong, Queen Mary Hospital, Hong Kong.
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| pubmed:publicationType |
Journal Article
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