Source:http://linkedlifedata.com/resource/pubmed/id/11520918
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
2001-8-24
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pubmed:abstractText |
Visual transduction captures widespread interest because its G-protein signaling motif recurs throughout nature yet is uniquely accessible for study in the photoreceptor cells. The light-activated currents generated at the photoreceptor outer segment provide an easily observed real-time measure of the output of the signaling cascade, and the ease of obtaining pure samples of outer segments in reasonable quantity facilitates biochemical experiments. A quiet revolution in the study of the mechanism has occurred during the past decade with the advent of gene-targeting techniques. These have made it possible to observe how transduction is perturbed by the deletion, overexpression, or mutation of specific components of the transduction apparatus.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0147-006X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
779-805
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11520918-Animals,
pubmed-meshheading:11520918-GTP-Binding Proteins,
pubmed-meshheading:11520918-Humans,
pubmed-meshheading:11520918-Photoreceptor Cells, Vertebrate,
pubmed-meshheading:11520918-Retinal Cone Photoreceptor Cells,
pubmed-meshheading:11520918-Retinal Rod Photoreceptor Cells,
pubmed-meshheading:11520918-Signal Transduction,
pubmed-meshheading:11520918-Vision, Ocular
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pubmed:year |
2001
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pubmed:articleTitle |
Activation, deactivation, and adaptation in vertebrate photoreceptor cells.
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pubmed:affiliation |
Department of Neurobiology, Stanford University Medical Center, Stanford, California 94305, USA. mburns@stanford.edu dbaylor@stanford.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review
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