Linked Life Data

11520915

Source:http://linkedlifedata.com/resource/pubmed/id/11520915

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2001-8-24
pubmed:abstractText
A fundamental problem in neuroscience is understanding how a neuron transduces synaptic input into action potentials. The dendrites form the substrate for consolidating thousands of synaptic inputs and are the first stage for signal processing in the neuron. Traditionally, dendrites are viewed as passive structures whose main function is to funnel synaptic input into the soma. However, dendrites contain a wide variety of voltage- and time-dependent ion channels. When activated, the currents through these channels can alter the amplitude and time course of the synaptic input and under certain conditions even evoke all-or-none regenerative potentials. The synaptic input that ultimately reaches the soma is likely to be a highly transformed version of the original signal. Thus, a key step in understanding the relationship between synaptic input and neuronal firing is to elucidate the signal processing that occurs in the dendrites.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0147-006X
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
653-75
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Influence of dendritic conductances on the input-output properties of neurons.
pubmed:affiliation
Center for Neural Science, New York University, New York, New York 10003, USA. reyes@cns.nyu.edu
pubmed:publicationType
Journal Article, Review