Linked Life Data

11520677

Source:http://linkedlifedata.com/resource/pubmed/id/11520677

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2001-8-24
pubmed:abstractText
Dan is the founding member of the Dan family of secreted cytokines. All members of this family--which includes Gremlin, Cerberus, Dante, PRDC, and several genes identified as expressed sequence tags in the mouse--characterized to date have been shown to antagonize signaling by the bone morphogenetic protein (BMP) family. During mouse embryogenesis, Dan is expressed in a restricted and dynamic pattern. Major sites of transcription include the somites, the myotome and the cranial, and facial and limb mesenchyme. Xenopus Dan (XDan) shares over 76% amino acid identity with mouse Dan (mDan). Here we report that in Xenopus embryos, XDan is expressed both as a maternal transcript and at later stages in populations of cells associated with the cranial and trunk neural crest. The conservation of Dan expression in cells of the head mesenchyme between Xenopus and mouse embryos suggests an important role for BMP antagonists in these tissues.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0925-4773
pubmed:author
pubmed:issnType
Print
pubmed:volume
107
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
187-9
pubmed:dateRevised
2004-12-3
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Xenopus Dan, a member of the Dan gene family of BMP antagonists, is expressed in derivatives of the cranial and trunk neural crest.
pubmed:affiliation
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3202, USA.
pubmed:publicationType
Journal Article