| pubmed-article:11520074 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11520074 | lifeskim:mentions | umls-concept:C0015923 | lld:lifeskim |
| pubmed-article:11520074 | lifeskim:mentions | umls-concept:C0282641 | lld:lifeskim |
| pubmed-article:11520074 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11520074 | lifeskim:mentions | umls-concept:C1121402 | lld:lifeskim |
| pubmed-article:11520074 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:11520074 | lifeskim:mentions | umls-concept:C0443146 | lld:lifeskim |
| pubmed-article:11520074 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:11520074 | lifeskim:mentions | umls-concept:C1539477 | lld:lifeskim |
| pubmed-article:11520074 | lifeskim:mentions | umls-concept:C1423842 | lld:lifeskim |
| pubmed-article:11520074 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:11520074 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:11520074 | lifeskim:mentions | umls-concept:C0205284 | lld:lifeskim |
| pubmed-article:11520074 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:11520074 | lifeskim:mentions | umls-concept:C0522503 | lld:lifeskim |
| pubmed-article:11520074 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11520074 | pubmed:dateCreated | 2001-8-24 | lld:pubmed |
| pubmed-article:11520074 | pubmed:abstractText | To investigate the effects of overproduction of IL-12p40, a potent antagonist against IL-12, on lupus-like autoimmune disease in vivo, we generated p40 transgenic MRL-Fas(lprcg)/Fas(lprcg) mice. Serum p40 and IL-12 levels were 600- to 8000-fold and 3- to 20-fold higher in transgenic (p40-lpr(cg)) than nontransgenic (lpr(cg)) mice, respectively. Serum IFN-gamma levels increased after 3 months of age in lpr(cg) and this age-related increase was completely abrogated in p40-lpr(cg). Serum IL-4 levels were the same in both mice. Production of IgM and IgG anti-double-stranded DNA (dsDNA) antibodies was significantly lower in p40-lpr(cg). Anti-dsDNA antibodies decreased in Th1-dependent IgG2a but increased in the Th2-dependent IgG1 subclass significantly in p40-lpr(cg). Proteinuria, glomerulonephritis, and survival were only marginally ameliorated in p40-lpr(cg). The results suggest that excess p40 production in vivo may suppress Th1 responses in autoantibody and IFN-gamma production but lead to minimal improvement of clinical manifestations of autoimmune disease in this mouse model. | lld:pubmed |
| pubmed-article:11520074 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11520074 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11520074 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11520074 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11520074 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11520074 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11520074 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11520074 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11520074 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11520074 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11520074 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11520074 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11520074 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11520074 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11520074 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11520074 | pubmed:issn | 0008-8749 | lld:pubmed |
| pubmed-article:11520074 | pubmed:author | pubmed-author:YoshimotoTT | lld:pubmed |
| pubmed-article:11520074 | pubmed:author | pubmed-author:YasudaTT | lld:pubmed |
| pubmed-article:11520074 | pubmed:author | pubmed-author:MatsuzawaAA | lld:pubmed |
| pubmed-article:11520074 | pubmed:author | pubmed-author:TsuburaAA | lld:pubmed |
| pubmed-article:11520074 | pubmed:copyrightInfo | Copyright 2001 Academic Press. | lld:pubmed |
| pubmed-article:11520074 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11520074 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11520074 | pubmed:volume | 210 | lld:pubmed |
| pubmed-article:11520074 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11520074 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11520074 | pubmed:pagination | 77-86 | lld:pubmed |
| pubmed-article:11520074 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:11520074 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11520074 | pubmed:articleTitle | Clear suppression of Th1 responses but marginal amelioration of autoimmune manifestations by IL-12p40 transgene in MRL-FAS(lprcg)/FAS(lprcg) mice. | lld:pubmed |
| pubmed-article:11520074 | pubmed:affiliation | Laboratory Animal Research Center, University of Tokyo, Minato-ku, Tokyo, Japan. takuwa@med.toho-u.ac.jp | lld:pubmed |
| pubmed-article:11520074 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11520074 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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