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rdf:type |
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lifeskim:mentions |
umls-concept:C0015923,
umls-concept:C0026809,
umls-concept:C0205284,
umls-concept:C0282641,
umls-concept:C0301625,
umls-concept:C0443146,
umls-concept:C0522503,
umls-concept:C0871261,
umls-concept:C1121402,
umls-concept:C1423842,
umls-concept:C1539477,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
2
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pubmed:dateCreated |
2001-8-24
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pubmed:abstractText |
To investigate the effects of overproduction of IL-12p40, a potent antagonist against IL-12, on lupus-like autoimmune disease in vivo, we generated p40 transgenic MRL-Fas(lprcg)/Fas(lprcg) mice. Serum p40 and IL-12 levels were 600- to 8000-fold and 3- to 20-fold higher in transgenic (p40-lpr(cg)) than nontransgenic (lpr(cg)) mice, respectively. Serum IFN-gamma levels increased after 3 months of age in lpr(cg) and this age-related increase was completely abrogated in p40-lpr(cg). Serum IL-4 levels were the same in both mice. Production of IgM and IgG anti-double-stranded DNA (dsDNA) antibodies was significantly lower in p40-lpr(cg). Anti-dsDNA antibodies decreased in Th1-dependent IgG2a but increased in the Th2-dependent IgG1 subclass significantly in p40-lpr(cg). Proteinuria, glomerulonephritis, and survival were only marginally ameliorated in p40-lpr(cg). The results suggest that excess p40 production in vivo may suppress Th1 responses in autoantibody and IFN-gamma production but lead to minimal improvement of clinical manifestations of autoimmune disease in this mouse model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Anti-Idiotypic,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Antinuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Subunits
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0008-8749
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
210
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
77-86
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11520074-Aging,
pubmed-meshheading:11520074-Animals,
pubmed-meshheading:11520074-Antibodies, Anti-Idiotypic,
pubmed-meshheading:11520074-Antibodies, Antinuclear,
pubmed-meshheading:11520074-Antibody Specificity,
pubmed-meshheading:11520074-Antigens, CD95,
pubmed-meshheading:11520074-Autoimmune Diseases,
pubmed-meshheading:11520074-Crosses, Genetic,
pubmed-meshheading:11520074-DNA,
pubmed-meshheading:11520074-Dimerization,
pubmed-meshheading:11520074-Disease Models, Animal,
pubmed-meshheading:11520074-Female,
pubmed-meshheading:11520074-Gene Therapy,
pubmed-meshheading:11520074-Genes, Synthetic,
pubmed-meshheading:11520074-Immunoglobulin G,
pubmed-meshheading:11520074-Immunoglobulin M,
pubmed-meshheading:11520074-Interferon-gamma,
pubmed-meshheading:11520074-Interleukin-12,
pubmed-meshheading:11520074-Interleukin-4,
pubmed-meshheading:11520074-Kidney,
pubmed-meshheading:11520074-Lupus Erythematosus, Systemic,
pubmed-meshheading:11520074-Lupus Nephritis,
pubmed-meshheading:11520074-Lymphoproliferative Disorders,
pubmed-meshheading:11520074-Male,
pubmed-meshheading:11520074-Mice,
pubmed-meshheading:11520074-Mice, Inbred C57BL,
pubmed-meshheading:11520074-Mice, Inbred MRL lpr,
pubmed-meshheading:11520074-Mice, Transgenic,
pubmed-meshheading:11520074-Protein Subunits,
pubmed-meshheading:11520074-Proteinuria,
pubmed-meshheading:11520074-Sex Factors,
pubmed-meshheading:11520074-Th1 Cells,
pubmed-meshheading:11520074-Th2 Cells,
pubmed-meshheading:11520074-Transgenes
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pubmed:year |
2001
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pubmed:articleTitle |
Clear suppression of Th1 responses but marginal amelioration of autoimmune manifestations by IL-12p40 transgene in MRL-FAS(lprcg)/FAS(lprcg) mice.
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pubmed:affiliation |
Laboratory Animal Research Center, University of Tokyo, Minato-ku, Tokyo, Japan. takuwa@med.toho-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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