| pubmed-article:11519678 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11519678 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:11519678 | lifeskim:mentions | umls-concept:C0039005 | lld:lifeskim |
| pubmed-article:11519678 | lifeskim:mentions | umls-concept:C0038689 | lld:lifeskim |
| pubmed-article:11519678 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:11519678 | lifeskim:mentions | umls-concept:C0442027 | lld:lifeskim |
| pubmed-article:11519678 | lifeskim:mentions | umls-concept:C0038676 | lld:lifeskim |
| pubmed-article:11519678 | lifeskim:mentions | umls-concept:C0041041 | lld:lifeskim |
| pubmed-article:11519678 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:11519678 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11519678 | pubmed:dateCreated | 2001-8-24 | lld:pubmed |
| pubmed-article:11519678 | pubmed:abstractText | The pharmacokinetics were studied of sulfadimethoxine (SDM) or sulfamethoxazole (SMX) in combination with trimethoprim (TMP) administered as a single oral dose (25 mg + 5 mg per kg body weight) to two groups of 6 healthy pigs. The elimination half-lives of SMX and TMP were quite similar (2-3 h); SDM had a relatively long half-life of 13 h. Both sulfonamides (S) were exclusively metabolized to N4-acetyl derivatives but to different extents. The main metabolic pathway for TMP was O-demethylation and subsequent conjugation. In addition, the plasma concentrations of these drugs and their main metabolites after medication with different in-feed concentrations were determined. The drug (S:TMP) concentrations in the feed were 250:50, 500:100, and 1000:200 mg per kg. Steady-state concentrations were achieved within 48 h of feed medication, twice daily (SDM+TMP) or three times a day (SMX+TMP). Protein binding of SDM and its metabolite was high (>93%), whereas SMX, TMP and their metabolites showed moderate binding (48-75%). Feed medication with 500 ppm sulfonamide combined with 100 ppm TMP provided minimum steady-state plasma concentrations (C(ss,min)) higher than the concentration required for inhibition of the growth of 90% of Actinobacillus pleuropneumoniae strains (n = 20). | lld:pubmed |
| pubmed-article:11519678 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11519678 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11519678 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11519678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11519678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11519678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11519678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11519678 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11519678 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:11519678 | pubmed:issn | 0165-7380 | lld:pubmed |
| pubmed-article:11519678 | pubmed:author | pubmed-author:KuiperH AHA | lld:pubmed |
| pubmed-article:11519678 | pubmed:author | pubmed-author:van MiertA... | lld:pubmed |
| pubmed-article:11519678 | pubmed:author | pubmed-author:VerheijdenJ... | lld:pubmed |
| pubmed-article:11519678 | pubmed:author | pubmed-author:PijpersAA | lld:pubmed |
| pubmed-article:11519678 | pubmed:author | pubmed-author:MengelersM... | lld:pubmed |
| pubmed-article:11519678 | pubmed:author | pubmed-author:van GoghE RER | lld:pubmed |
| pubmed-article:11519678 | pubmed:author | pubmed-author:HuveneersM... | lld:pubmed |
| pubmed-article:11519678 | pubmed:author | pubmed-author:HougeeP EPE | lld:pubmed |
| pubmed-article:11519678 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11519678 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:11519678 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11519678 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11519678 | pubmed:pagination | 461-81 | lld:pubmed |
| pubmed-article:11519678 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11519678 | pubmed:meshHeading | pubmed-meshheading:11519678... | lld:pubmed |
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| pubmed-article:11519678 | pubmed:meshHeading | pubmed-meshheading:11519678... | lld:pubmed |
| pubmed-article:11519678 | pubmed:meshHeading | pubmed-meshheading:11519678... | lld:pubmed |
| pubmed-article:11519678 | pubmed:meshHeading | pubmed-meshheading:11519678... | lld:pubmed |
| pubmed-article:11519678 | pubmed:meshHeading | pubmed-meshheading:11519678... | lld:pubmed |
| pubmed-article:11519678 | pubmed:meshHeading | pubmed-meshheading:11519678... | lld:pubmed |
| pubmed-article:11519678 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11519678 | pubmed:articleTitle | Pharmacokinetics of sulfadimethoxine and sulfamethoxazole in combination with trimethoprim after oral single- and multiple-dose administration to healthy pigs. | lld:pubmed |
| pubmed-article:11519678 | pubmed:affiliation | State Institute for Quality Control of Agricultural Products, Department of Toxicology, Wageningen, The Netherlands. | lld:pubmed |
| pubmed-article:11519678 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11519678 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
