Linked Life Data

1151957

Source:http://linkedlifedata.com/resource/pubmed/id/1151957

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1975-11-6
pubmed:abstractText
A series of analogs of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC)was prepared and tested for porphyria-inducing activity in chick embryo liver cells. One of the analogs tested, viz.3,5-di-tert-butoxycarbonyl-1,4-dihydro-2,6-dimethylpyridine, was found to be highly active despite the absence of a 4-alkyl substituent. It was concluded that tert-butoxycarbonyl groups are resistant to enzymic hydrolysis and that compounds containing such groups are resistant to inactivation by chick embryo liver cells. Several analogs of DDC were found with considerably higher activity. These should be useful in inducing high levels of beta-aminolevulinic acid synthetase prior to undertaking the isolation of the enzyme.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-2623
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
457-60
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Porphyria-inducing activity of a series of pyridine and dihydropyridine compounds. Investigation in a cell culture system.
pubmed:publicationType
Journal Article