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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2001-8-24
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pubmed:abstractText |
We recently reported that treatment of uremic rats with reduced renal mass with the angiotensin II (Ang II) subtype 1 receptor (AT1) antagonist losartan reduces endothelin-1 (ET-1) levels in blood vessels and in glomeruli. Although this suggests an important role for Ang II in the modulation of ET-1 production, the concomitant decrease in blood pressure may also be involved. The present study was designed to investigate whether the modulation of ET-1 production in uremic rats is related to tissue-specific effects of AT1 receptor blockade or to the antihypertensive effect of losartan.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0263-6352
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1479-87
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11518857-Angiotensin Receptor Antagonists,
pubmed-meshheading:11518857-Animals,
pubmed-meshheading:11518857-Antihypertensive Agents,
pubmed-meshheading:11518857-Blood Pressure,
pubmed-meshheading:11518857-Endothelin-1,
pubmed-meshheading:11518857-Endothelins,
pubmed-meshheading:11518857-Hypertension,
pubmed-meshheading:11518857-Kidney,
pubmed-meshheading:11518857-Losartan,
pubmed-meshheading:11518857-Male,
pubmed-meshheading:11518857-Protein Precursors,
pubmed-meshheading:11518857-Rats,
pubmed-meshheading:11518857-Rats, Sprague-Dawley,
pubmed-meshheading:11518857-Receptor, Angiotensin, Type 1,
pubmed-meshheading:11518857-Systole,
pubmed-meshheading:11518857-Uremia
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pubmed:year |
2001
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pubmed:articleTitle |
Blood pressure-independent effect of angiotensin AT1 receptor blockade on renal endothelin-1 production in hypertensive uremic rats.
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pubmed:affiliation |
Research Center and Division of Nephrology, CHUQ, L'Hôtel-Dieu de Québec, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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