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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1975-11-8
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pubmed:abstractText |
This isolated, perfused ear artery of the rabbit has been used to examine the effect of alterations in muscle load on the construction of arteries. The equilibrium muscle load, taken as the difference in wall stress between the relaxed and constricted artery at the same external radius, was varied by changing the transmural pressure and by constricting the artery. 2. The equilibrium muscle load increased initially and then declined with decreasing external radius when the transmural pressure was kept constant. The maximum muscle load was reached when the relaxed external radius had been reduced by 11% at 80 mmHg and by 4-5% (relative to the radius at 80 mmHg) at 160 mmHg. 3. Arteries from young rabbits (3-6 months in age) which were partially constricted by adrenaline or spontaneous activity responded better to 60 sec of 4 Hz field stimulation at transmural pressures above 100 mmHg than did relaxed arteries. Neither field stimulation nor high concentrations of noradrenaline ( is greater than 800 ng/ml.) were able to constrict most arteries effectively at pressures above 160-170 mmHg unless partial constriction was present. The partial constriction reduced the load placed on the muscle by the same transmural pressure. Constrictio n during field stimulation was due largely to the release of neurotransmitter. 4. Ear arteries from young and older rabbits differed little in their ability to constrict against different transmural pressures. The one major difference was a lesser maximum constriction of arteries from older rabbits (18-24 months in age). However, arteries from older rabbits constricted well at the higher transmural pressures only because wall thickening largely compensated for a decreased ability of the muscle to develop active tension. 5. It is concluded that a decrease in internal radius to wall thickness ratio by either sufficient partial vasoconstriction or by wall thickening favours constriction of arteries because the load placed on the muscle by the same transmural pressure is reduced. Wall thickening may be an important compensatory reaction for deteriorating muscle contraction.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1151836-13097395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1151836-16992066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1151836-4256989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1151836-4304030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1151836-4337380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1151836-4339955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1151836-4358201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1151836-4579661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1151836-4746719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1151836-4878307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1151836-4888390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1151836-5027081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1151836-5058383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1151836-5060229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1151836-5060432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1151836-5130334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1151836-5169238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1151836-5323224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1151836-5353039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1151836-5661939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1151836-5904163
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-3751
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
248
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
531-53
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1151836-Animals,
pubmed-meshheading:1151836-Arteries,
pubmed-meshheading:1151836-Constriction,
pubmed-meshheading:1151836-Ear,
pubmed-meshheading:1151836-Electric Stimulation,
pubmed-meshheading:1151836-Epinephrine,
pubmed-meshheading:1151836-Female,
pubmed-meshheading:1151836-Male,
pubmed-meshheading:1151836-Muscle, Smooth,
pubmed-meshheading:1151836-Norepinephrine,
pubmed-meshheading:1151836-Perfusion,
pubmed-meshheading:1151836-Pressure,
pubmed-meshheading:1151836-Rabbits,
pubmed-meshheading:1151836-Vasoconstrictor Agents
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pubmed:year |
1975
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pubmed:articleTitle |
Muscle load and constriction of the rabbit ear artery.
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pubmed:publicationType |
Journal Article,
In Vitro
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