Linked Life Data

1151746

Source:http://linkedlifedata.com/resource/pubmed/id/1151746

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1975-10-30
pubmed:abstractText
An antibody to serotonin (5-HT) was tested on several preparations in which 5-HT is considered to be involved. The antibody was capable of effectively competing with 5-HT receptor sites for free molecules of 5-HT. It inhibited the uptake of 3H-5HT by blood platelets and may explain the reduced endogenous 5-HT concentration in blood platelets of immunized rabbits. The decreased platelet content of 5-HT was substantiated by electron microscopic studies which showed a reduction in the number of 5-HT-containing subcellular storage organelles in platelets from these animals. The 5-HT antibody inhibited the 5-HT-induced contraction of aortic strips in a tissue bath preparation. When given intraventricularly, it inhibited for a time the sedative actions of reserpine thus adding new evidence to the often postulated role of 5-HT in the actions of reserpine.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
194
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
145-53
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Immunopharmacological studies using 5-hydroxytryptamine antibody.
pubmed:publicationType
Journal Article