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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2001-8-22
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pubmed:abstractText |
The development and activation of CD4+ helper T cell (Th) subsets with distinct patterns of unbalanced production of cytokines play an important part in infectious, allergic and autoimmune diseases. Human neonatal cord blood CD4+ Th cells can be polarized into type 1 or type 2-like effector cells in vitro by culturing them in the presence of interleukin (IL)-12 or IL-4, respectively. We have exploited this experimental system to identify marker genes that are differentially expressed by polarized Th1 and Th2 cells. An oligonucleotide microarray specifically designed to screen for inflammation-related candidate genes was used and the differential expression was further validated with a quantitative real-time RT-PCR method.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1465-6914
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
RESEARCH0022
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11516335-Antigens, CD4,
pubmed-meshheading:11516335-Cytokines,
pubmed-meshheading:11516335-Gene Expression Profiling,
pubmed-meshheading:11516335-Humans,
pubmed-meshheading:11516335-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:11516335-RNA,
pubmed-meshheading:11516335-Receptors, Cytokine,
pubmed-meshheading:11516335-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:11516335-Sensitivity and Specificity,
pubmed-meshheading:11516335-Th1 Cells,
pubmed-meshheading:11516335-Th2 Cells
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pubmed:year |
2001
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pubmed:articleTitle |
Distinct gene expression profiles of human type 1 and type 2 T helper cells.
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pubmed:affiliation |
Turku Centre for Biotechnology, University of Turku and Abo Akademi University, FIN-20521 Turku, Finland.
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pubmed:publicationType |
Journal Article
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