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rdf:type |
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lifeskim:mentions |
umls-concept:C0003015,
umls-concept:C0017262,
umls-concept:C0033085,
umls-concept:C0034693,
umls-concept:C0152171,
umls-concept:C0185117,
umls-concept:C0249197,
umls-concept:C0288472,
umls-concept:C0907532,
umls-concept:C1420626,
umls-concept:C2911684
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pubmed:issue |
8
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pubmed:dateCreated |
2001-8-21
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pubmed:abstractText |
Pulmonary arterial hypertension (PAH) is associated with structural changes in the pulmonary vasculature characterized by the proliferation of cellular components of the vessels. ACE inhibitor (ACEI) may have beneficial effects in treating PAH, but its precise mechanism of action in the remodeling process is unclear. p21 is a cyclin-dependent kinase inhibitor that may have a protective role in this process by inhibiting cellular proliferation. Endothelial nitric oxide synthase (eNOS) has also been shown to be protective by its vasodilatory effect. Therefore, we investigated whether expression of p21 and eNOS was modulated by ACEI treatment in a rat model.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin-Converting Enzyme...,
http://linkedlifedata.com/resource/pubmed/chemical/Cdkn1a protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclins,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats,
http://linkedlifedata.com/resource/pubmed/chemical/Enalapril,
http://linkedlifedata.com/resource/pubmed/chemical/Monocrotaline,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrates,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Donors,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrites,
http://linkedlifedata.com/resource/pubmed/chemical/Nos3 protein, rat
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
21
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
945-50
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11514384-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:11514384-Animals,
pubmed-meshheading:11514384-Blood Pressure,
pubmed-meshheading:11514384-Cells, Cultured,
pubmed-meshheading:11514384-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:11514384-Cyclins,
pubmed-meshheading:11514384-Dietary Fats,
pubmed-meshheading:11514384-Disease Models, Animal,
pubmed-meshheading:11514384-Enalapril,
pubmed-meshheading:11514384-Hypertension, Pulmonary,
pubmed-meshheading:11514384-Hypertrophy, Right Ventricular,
pubmed-meshheading:11514384-Lung,
pubmed-meshheading:11514384-Magnetic Resonance Imaging,
pubmed-meshheading:11514384-Male,
pubmed-meshheading:11514384-Monocrotaline,
pubmed-meshheading:11514384-Nitrates,
pubmed-meshheading:11514384-Nitric Oxide Donors,
pubmed-meshheading:11514384-Nitric Oxide Synthase,
pubmed-meshheading:11514384-Nitric Oxide Synthase Type III,
pubmed-meshheading:11514384-Nitrites,
pubmed-meshheading:11514384-Perfusion,
pubmed-meshheading:11514384-Pulmonary Artery,
pubmed-meshheading:11514384-Rats,
pubmed-meshheading:11514384-Rats, Sprague-Dawley,
pubmed-meshheading:11514384-Signal Transduction
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pubmed:year |
2001
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pubmed:articleTitle |
Angiotensin-converting enzyme inhibitor preserves p21 and endothelial nitric oxide synthase expression in monocrotaline-induced pulmonary arterial hypertension in rats.
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pubmed:affiliation |
Department of Biological Sciences and Pittsburgh NMR Center for Biomedical Research, Carnegie-Mellon University, Pittsburgh, PA 15213-2683, USA. skanno@andrew.cmu.edu
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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