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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2001-8-21
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pubmed:abstractText |
The goal of this study was to examine whether alteration of sarcoplasmic reticulum (SR) protein levels is associated with early-onset diastolic and late-onset systolic dysfunction in streptozotocin (STZ)-induced diabetic rat hearts. Four-week diabetic rat hearts exhibited slow relaxation, whereas 6-wk diabetic rat hearts exhibited slow and depressed contraction. Total phospholamban level was increased, and phosphorylated level was decreased in 4- and 6-wk diabetic rat hearts. Sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA2) protein level was unchanged in 4-wk but decreased in 6-wk diabetic rat hearts. Only the apparent affinity of SR Ca2+ uptake for Ca2+ was decreased in 4-wk diabetic rat hearts, but the apparent affinity and the maximum rate was decreased in 6-wk diabetic rat hearts. Insulin treatment of the diabetic rats normalized SR protein expression and function. It was concluded that an increase in nonphosphorylated phospholamban and a decrease in the apparent affinity of SR Ca2+ pump for Ca2+ are associated with early-onset diastolic dysfunction and decreases in SERCA2 protein level and apparent affinity and maximum velocity of SR Ca2+ pump are associated with late-onset systolic dysfunction in diabetic rats.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Atp2a2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Transporting ATPases,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Muscle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ryanodine Receptor Calcium Release...,
http://linkedlifedata.com/resource/pubmed/chemical/Sarcoplasmic Reticulum...,
http://linkedlifedata.com/resource/pubmed/chemical/Streptozocin,
http://linkedlifedata.com/resource/pubmed/chemical/phospholamban
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0363-6135
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
281
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
H1137-47
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11514280-Animals,
pubmed-meshheading:11514280-Blood Glucose,
pubmed-meshheading:11514280-Body Weight,
pubmed-meshheading:11514280-Calcium,
pubmed-meshheading:11514280-Calcium-Binding Proteins,
pubmed-meshheading:11514280-Calcium-Transporting ATPases,
pubmed-meshheading:11514280-Diabetes Mellitus, Experimental,
pubmed-meshheading:11514280-Diastole,
pubmed-meshheading:11514280-Heart,
pubmed-meshheading:11514280-Heart Rate,
pubmed-meshheading:11514280-Insulin,
pubmed-meshheading:11514280-Male,
pubmed-meshheading:11514280-Muscle Proteins,
pubmed-meshheading:11514280-Myocardial Contraction,
pubmed-meshheading:11514280-Organ Size,
pubmed-meshheading:11514280-Phosphorylation,
pubmed-meshheading:11514280-Rats,
pubmed-meshheading:11514280-Rats, Wistar,
pubmed-meshheading:11514280-Ryanodine Receptor Calcium Release Channel,
pubmed-meshheading:11514280-Sarcoplasmic Reticulum,
pubmed-meshheading:11514280-Sarcoplasmic Reticulum Calcium-Transporting ATPases,
pubmed-meshheading:11514280-Streptozocin
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pubmed:year |
2001
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pubmed:articleTitle |
Altered SR protein expression associated with contractile dysfunction in diabetic rat hearts.
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pubmed:affiliation |
Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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