Source:http://linkedlifedata.com/resource/pubmed/id/11513873
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2-3
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pubmed:dateCreated |
2001-8-21
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pubmed:abstractText |
Pancreatic cancer cells are usually resistant to apoptosis mediated by intrinsic or extrinsic factors. BAG-3 (Bis, CAIR), which was identified as a BAG-1-related protein, is a novel modulator of cellular anti-apoptotic activity that functions through its interaction with Bcl-2. In this study we analyzed BAG-3 expression in human pancreatic cancer tissues and cell lines. BAG-3 mRNA was expressed at moderate to high levels in all pancreatic cancer samples, but at low levels in normal pancreas tissues. In situ hybridization and immunohistochemistry analysis revealed that BAG-3 was present in the cancer cells within the pancreatic tumor mass. When BAG-3 mRNA was analyzed in other gastrointestinal cancers (hepatocellular carcinoma; esophageal, stomach and colon cancer), no difference was found from their corresponding normal controls. In pancreatic cancer cells, BAG-3 mRNA expression levels were strongly induced after heat stress, but not in response to members of the tumor necrosis factor (TNF)-alpha family (TNF-alpha, TRAIL, FasL). These findings indicate that in pancreatic cancer, in contrast to other gastrointestinal malignancies, increased levels of BAG-3 might function to block apoptosis. This characteristic of pancreatic cancer might contribute to its more aggressive growth behavior and poor responsiveness to treatment in vivo.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/BAG3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0014-5793
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
503
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
151-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11513873-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:11513873-Apoptosis,
pubmed-meshheading:11513873-Base Sequence,
pubmed-meshheading:11513873-Carrier Proteins,
pubmed-meshheading:11513873-DNA Primers,
pubmed-meshheading:11513873-Gene Expression,
pubmed-meshheading:11513873-Hot Temperature,
pubmed-meshheading:11513873-Humans,
pubmed-meshheading:11513873-Immunohistochemistry,
pubmed-meshheading:11513873-In Situ Hybridization,
pubmed-meshheading:11513873-Pancreas,
pubmed-meshheading:11513873-Pancreatic Neoplasms,
pubmed-meshheading:11513873-RNA, Messenger,
pubmed-meshheading:11513873-RNA, Neoplasm,
pubmed-meshheading:11513873-Tumor Cells, Cultured,
pubmed-meshheading:11513873-Tumor Necrosis Factor-alpha
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pubmed:year |
2001
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pubmed:articleTitle |
The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines.
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pubmed:affiliation |
Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland.
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pubmed:publicationType |
Journal Article
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