Source:http://linkedlifedata.com/resource/pubmed/id/11513327
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
2001-8-21
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pubmed:abstractText |
Treatment with hyperbaric O2 (HBO) ameliorates ischemia-reperfusion (I/R) injury. Since tumor necrosis factor-alpha (TNF-alpha) plays an important role in I/R injury, we hypothesized that the effect of HBO in I/R injury may be due to its ability to inhibit TNF-alpha production. In this study, one group of rats received HBO during 60 min of ischemia (HBO group, n = 9), while control rats endured the same procedure but did not receive HBO (non-HBO, n = 9). A group of sham-operated control rats (SHAM, n = 6) underwent laparotomy without occlusion of the artery and HBO treatment. Intestinal I/R led to an increase in serum TNF-alpha concentration to [mean (SEM)] 165 (32) pg/ml (P < 0.01 vs SHAM rats). HBO attenuated this increase [34 (9) pg/ml; P<0.05 vs non-HBO group]. Intestinal I/R also resulted in a marked increase in lung myeloperoxidase content [0.62 (0.04) U/g vs 0.17 (0.02) U/g of SHAM rats, P<0.01]. HBO suppressed this increase [0.40 (0.04) U/g, P<0.05 vs non-HBO rats]. HBO ameliorated the injury to the intestine and lung. The number of neutrophils sequestered in the lung was reduced in HBO rats compared to non-HBO rats [6.4 (0.9) neutrophils/per oil field and 10.9 (2) neutrophils/per oil field, respectively; P < 0.05]. These findings demonstrate that HBO inhibits TNF-alpha production during intestinal I/R, and this reduced TNF-alpha production may be attributed to the beneficial effects of HBO.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1439-6319
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
96-103
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:11513327-Acute Disease,
pubmed-meshheading:11513327-Animals,
pubmed-meshheading:11513327-Hyperbaric Oxygenation,
pubmed-meshheading:11513327-Intestines,
pubmed-meshheading:11513327-Lung,
pubmed-meshheading:11513327-Male,
pubmed-meshheading:11513327-Microvilli,
pubmed-meshheading:11513327-Neutrophils,
pubmed-meshheading:11513327-Peroxidase,
pubmed-meshheading:11513327-Rats,
pubmed-meshheading:11513327-Rats, Sprague-Dawley,
pubmed-meshheading:11513327-Reperfusion Injury,
pubmed-meshheading:11513327-Specific Pathogen-Free Organisms,
pubmed-meshheading:11513327-Tumor Necrosis Factor-alpha
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pubmed:year |
2001
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pubmed:articleTitle |
Hyperbaric O2 reduces intestinal ischemia-reperfusion-induced TNF-alpha production and lung neutrophil sequestration.
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pubmed:affiliation |
Department of Anesthesiology, New York Upstate Medical Center, State University of New York, Syracuse 13210, USA. yangz@upstate.edu
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pubmed:publicationType |
Journal Article
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