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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2001-8-20
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pubmed:abstractText |
A direct liquid chromatography method was developed for the diastereo- and enantioselective analysis of a C3,C4-substituted beta-lactamic hypolipodemic agent (SCH 48461) and its stereoisomers on two commercially available amylose-based chiral stationary phases (CSPs), namely, Chiralpak AS and Chiralpak AD. The mobile phase composition (type and content of alcoholic modifier) was considered to achieve baseline resolutions in a single chromatographic run. In order to investigate the influence of molecular flexibility on chiral recognition process, beta-lactams were ring-opened and converted into beta-amino esters derivatives. Thermodynamic parameters associated with adsorption equilibria between acyclic and cyclic stereoisomers and CSPs were calculated from chromatographic runs at various temperatures.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0021-9673
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
923
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
27-36
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pubmed:dateRevised |
2009-1-15
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pubmed:meshHeading |
pubmed-meshheading:11510550-Amylose,
pubmed-meshheading:11510550-Anticholesteremic Agents,
pubmed-meshheading:11510550-Azetidines,
pubmed-meshheading:11510550-Carbamates,
pubmed-meshheading:11510550-Chromatography, High Pressure Liquid,
pubmed-meshheading:11510550-Molecular Conformation,
pubmed-meshheading:11510550-Phenylcarbamates,
pubmed-meshheading:11510550-Stereoisomerism,
pubmed-meshheading:11510550-Temperature,
pubmed-meshheading:11510550-Thermodynamics,
pubmed-meshheading:11510550-beta-Lactams
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pubmed:year |
2001
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pubmed:articleTitle |
Conformational and temperature effects on separation of stereoisomers of a C3,C4-substituted beta-lactamic cholesterol absorption inhibitor on amylose-based chiral stationary phases.
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pubmed:affiliation |
Istituto Superiore di Sanità, Laboratorio di Chimica del Farmaco, Rome, Italy.
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pubmed:publicationType |
Journal Article
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