11510300

Source:http://linkedlifedata.com/resource/pubmed/id/11510300

Download in:

Switch to

Custom View

Named Graph Language Inference

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0001047, umls-concept:C0011947, umls-concept:C0021469, umls-concept:C0074771, umls-concept:C0205179, umls-concept:C0442796, umls-concept:C0598528, umls-concept:C1156395, umls-concept:C1514468, umls-concept:C1522492
pubmed:dateCreated	2001-8-20
pubmed:abstractText	The present study evaluated the inhibiting effect of various chemicals on the advanced glycation end-product (AGEs) cross-linking caused in protein by glucose degradation products (GDPs). We evaluated a few dozen organic and inorganic chemicals--in addition to previously reported AGE inhibitors, such as thiazolium derivatives and aminoguanidine--for their inhibiting effect. Collagen IV (from human placenta) or human serum albumin (HSA) was incubated with an AGE accelerator and one of the selected chemicals in phosphate buffer solution at 37 degrees C for as long as 14 days. Fluorescence intensity (440 nm) was determined after a given incubation time. Among 36 chemicals tested, 8 new chemicals and 5 previously known AGE inhibitors significantly suppressed the increase in fluorescence intensity seen after incubation of HSA with methylglyoxal. We believe that 6 chemicals may effectively quench GDPs and inhibit AGE cross-link formation, in a manner different from that of aminoguanidine and thiazolium.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9104803
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/3-deoxyglucosone, http://linkedlifedata.com/resource/pubmed/chemical/Acetylcysteine, http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type IV, http://linkedlifedata.com/resource/pubmed/chemical/Deoxyglucose, http://linkedlifedata.com/resource/pubmed/chemical/Dialysis Solutions, http://linkedlifedata.com/resource/pubmed/chemical/Glucose, http://linkedlifedata.com/resource/pubmed/chemical/Glycosylation End Products, Advanced, http://linkedlifedata.com/resource/pubmed/chemical/Glyoxylates, http://linkedlifedata.com/resource/pubmed/chemical/Pyruvaldehyde, http://linkedlifedata.com/resource/pubmed/chemical/Serum Albumin, http://linkedlifedata.com/resource/pubmed/chemical/Sulfites, http://linkedlifedata.com/resource/pubmed/chemical/sodium sulfite
pubmed:status	MEDLINE
pubmed:issn	1197-8554
pubmed:author	pubmed-author:NakamotoMM, pubmed-author:NakayamaMM, pubmed-author:NumataMM, pubmed-author:SakaiAA, pubmed-author:TakesawaSS
pubmed:issnType	Print
pubmed:volume	17
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	66-70
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:11510300-Acetylcysteine, pubmed-meshheading:11510300-Collagen Type IV, pubmed-meshheading:11510300-Deoxyglucose, pubmed-meshheading:11510300-Dialysis Solutions, pubmed-meshheading:11510300-Fluorescence, pubmed-meshheading:11510300-Glucose, pubmed-meshheading:11510300-Glycosylation End Products, Advanced, pubmed-meshheading:11510300-Glyoxylates, pubmed-meshheading:11510300-Humans, pubmed-meshheading:11510300-Pyruvaldehyde, pubmed-meshheading:11510300-Serum Albumin, pubmed-meshheading:11510300-Sulfites
pubmed:year	2001
pubmed:articleTitle	Sodium sulfite and N-acetylcysteine: new additives to dialysate for inhibiting formation of glucose degradation products and advanced glycation end-products.
pubmed:affiliation	Peritoneal Dialysis Research Project, Japan Science and Technology Corporation, c/o Tokyo Metropolitan Industrial Technology Research Institute, 11-1 Fukazawa 2-chome, Setagaya-ku, Tokyo 158-0081, Japan.
pubmed:publicationType	Journal Article, In Vitro, Research Support, Non-U.S. Gov't