Source:http://linkedlifedata.com/resource/pubmed/id/11510294
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2001-8-20
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| pubmed:abstractText |
Phosphate-buffered saline (PBS), an isotonic solution with a physiologic pH can be considered an example of a biocompatible dialysis fluid. This study compared the biocompatibility of PBS with that of Dianeal 3.86% (Baxter Healthcare Corporation, Deerfield, IL, U.S.A.), using a model of peritoneal dialysis in the rat. In an acute experiment, after catheter implantation, rats were infused on day 1 with PBS, on day 5 with standard dialysis solution (Dianeal 3.86%), and on day 7 again with PBS. When rats were injected with Dianeal 3.86%, the inflammatory reaction was suppressed as compared with PBS. The cell count was lower with Dianeal (-85%, p < 0.001), the neutrophil:macrophage ratio in dialysate was 80% lower (p < 0.01), total protein concentration in the Dianeal dialysate was 73% lower (p < 0.01), and the dialysate nitrite level was 45% lower (p < 0.01). In a chronic experiment, after catheter implantation, rats were dialyzed for four weeks with PBS or with Dianeal 3.86%. At the end of the study, a 1-hour peritoneal equilibration test (PET) was performed. As evaluated on a semiquantitative scale, macroscopic changes in the peritoneum were more severe in rats exposed to PBS than in those exposed to Dianeal 3.86% (8.6 +/- 3.2 vs 5.2 +/- 2.6, p < 0.05). The thickness of the visceral peritoneum was comparable in both groups; but, in PBS-treated rats, the peritoneal interstitium contained more inflammatory cells and more new vessels. During the 1-hour PET, peritoneal permeability to water and solutes was comparable in the two groups. Despite a more physiologic composition, PBS is a less biocompatible peritoneal dialysis solutions than is standard, acidic, hypertonic dialysis solution.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biocompatible Materials,
http://linkedlifedata.com/resource/pubmed/chemical/Buffers,
http://linkedlifedata.com/resource/pubmed/chemical/Dialysis Solutions,
http://linkedlifedata.com/resource/pubmed/chemical/Hypertonic Solutions,
http://linkedlifedata.com/resource/pubmed/chemical/Isotonic Solutions,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrites,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Chloride
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| pubmed:status |
MEDLINE
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| pubmed:issn |
1197-8554
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
17
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
42-6
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11510294-Animals,
pubmed-meshheading:11510294-Biocompatible Materials,
pubmed-meshheading:11510294-Buffers,
pubmed-meshheading:11510294-Cell Count,
pubmed-meshheading:11510294-Dialysis Solutions,
pubmed-meshheading:11510294-Hydrogen-Ion Concentration,
pubmed-meshheading:11510294-Hypertonic Solutions,
pubmed-meshheading:11510294-Isotonic Solutions,
pubmed-meshheading:11510294-Macrophages,
pubmed-meshheading:11510294-Male,
pubmed-meshheading:11510294-Neutrophils,
pubmed-meshheading:11510294-Nitrites,
pubmed-meshheading:11510294-Peritoneal Dialysis,
pubmed-meshheading:11510294-Peritoneum,
pubmed-meshheading:11510294-Phosphates,
pubmed-meshheading:11510294-Proteins,
pubmed-meshheading:11510294-Rats,
pubmed-meshheading:11510294-Rats, Wistar,
pubmed-meshheading:11510294-Sodium Chloride
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| pubmed:year |
2001
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| pubmed:articleTitle |
A comparison of the biocompatibility of phosphate-buffered saline and dianeal 3.86% in the rat model of peritoneal dialysis.
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| pubmed:affiliation |
University Medical School of Poznan, Poznan, Poland.
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| pubmed:publicationType |
Journal Article,
Comparative Study
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