| pubmed-article:11509722 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11509722 | lifeskim:mentions | umls-concept:C0220806 | lld:lifeskim |
| pubmed-article:11509722 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:11509722 | lifeskim:mentions | umls-concept:C1705920 | lld:lifeskim |
| pubmed-article:11509722 | lifeskim:mentions | umls-concept:C1721063 | lld:lifeskim |
| pubmed-article:11509722 | lifeskim:mentions | umls-concept:C1881982 | lld:lifeskim |
| pubmed-article:11509722 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:11509722 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:11509722 | lifeskim:mentions | umls-concept:C0332324 | lld:lifeskim |
| pubmed-article:11509722 | pubmed:issue | 5533 | lld:pubmed |
| pubmed-article:11509722 | pubmed:dateCreated | 2001-8-17 | lld:pubmed |
| pubmed-article:11509722 | pubmed:abstractText | Boron-doped silicon nanowires (SiNWs) were used to create highly sensitive, real-time electrically based sensors for biological and chemical species. Amine- and oxide-functionalized SiNWs exhibit pH-dependent conductance that was linear over a large dynamic range and could be understood in terms of the change in surface charge during protonation and deprotonation. Biotin-modified SiNWs were used to detect streptavidin down to at least a picomolar concentration range. In addition, antigen-functionalized SiNWs show reversible antibody binding and concentration-dependent detection in real time. Lastly, detection of the reversible binding of the metabolic indicator Ca2+ was demonstrated. The small size and capability of these semiconductor nanowires for sensitive, label-free, real-time detection of a wide range of chemical and biological species could be exploited in array-based screening and in vivo diagnostics. | lld:pubmed |
| pubmed-article:11509722 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11509722 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11509722 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11509722 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:11509722 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:11509722 | pubmed:author | pubmed-author:ParkHH | lld:pubmed |
| pubmed-article:11509722 | pubmed:author | pubmed-author:CuiYY | lld:pubmed |
| pubmed-article:11509722 | pubmed:author | pubmed-author:WeiQQ | lld:pubmed |
| pubmed-article:11509722 | pubmed:author | pubmed-author:LieberC MCM | lld:pubmed |
| pubmed-article:11509722 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11509722 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:11509722 | pubmed:volume | 293 | lld:pubmed |
| pubmed-article:11509722 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11509722 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11509722 | pubmed:pagination | 1289-92 | lld:pubmed |
| pubmed-article:11509722 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11509722 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11509722 | pubmed:articleTitle | Nanowire nanosensors for highly sensitive and selective detection of biological and chemical species. | lld:pubmed |
| pubmed-article:11509722 | pubmed:affiliation | Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA. | lld:pubmed |
| pubmed-article:11509722 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11509722 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:11509722 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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