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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5533
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pubmed:dateCreated |
2001-8-17
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pubmed:abstractText |
Boron-doped silicon nanowires (SiNWs) were used to create highly sensitive, real-time electrically based sensors for biological and chemical species. Amine- and oxide-functionalized SiNWs exhibit pH-dependent conductance that was linear over a large dynamic range and could be understood in terms of the change in surface charge during protonation and deprotonation. Biotin-modified SiNWs were used to detect streptavidin down to at least a picomolar concentration range. In addition, antigen-functionalized SiNWs show reversible antibody binding and concentration-dependent detection in real time. Lastly, detection of the reversible binding of the metabolic indicator Ca2+ was demonstrated. The small size and capability of these semiconductor nanowires for sensitive, label-free, real-time detection of a wide range of chemical and biological species could be exploited in array-based screening and in vivo diagnostics.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Biotin,
http://linkedlifedata.com/resource/pubmed/chemical/Boron,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Calmodulin,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protons,
http://linkedlifedata.com/resource/pubmed/chemical/Silicon,
http://linkedlifedata.com/resource/pubmed/chemical/Streptavidin
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
293
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1289-92
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11509722-Antibodies, Monoclonal,
pubmed-meshheading:11509722-Biosensing Techniques,
pubmed-meshheading:11509722-Biotin,
pubmed-meshheading:11509722-Boron,
pubmed-meshheading:11509722-Calcium,
pubmed-meshheading:11509722-Calmodulin,
pubmed-meshheading:11509722-Chemistry Techniques, Analytical,
pubmed-meshheading:11509722-Electric Conductivity,
pubmed-meshheading:11509722-Hydrogen-Ion Concentration,
pubmed-meshheading:11509722-Ligands,
pubmed-meshheading:11509722-Miniaturization,
pubmed-meshheading:11509722-Proteins,
pubmed-meshheading:11509722-Protons,
pubmed-meshheading:11509722-Semiconductors,
pubmed-meshheading:11509722-Sensitivity and Specificity,
pubmed-meshheading:11509722-Silicon,
pubmed-meshheading:11509722-Streptavidin,
pubmed-meshheading:11509722-Surface Properties
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pubmed:year |
2001
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pubmed:articleTitle |
Nanowire nanosensors for highly sensitive and selective detection of biological and chemical species.
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pubmed:affiliation |
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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