| pubmed-article:11509604 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11509604 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:11509604 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:11509604 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:11509604 | lifeskim:mentions | umls-concept:C1159978 | lld:lifeskim |
| pubmed-article:11509604 | lifeskim:mentions | umls-concept:C0449379 | lld:lifeskim |
| pubmed-article:11509604 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:11509604 | pubmed:dateCreated | 2001-8-17 | lld:pubmed |
| pubmed-article:11509604 | pubmed:abstractText | Osteoclasts differentiate from the hemopoietic monocyte/macrophage cell lineage in bone marrow through cell-cell interactions between osteoclast progenitors and stromal/osteoblastic cells. Here we show another osteoclast differentiation pathway closely connected with B lymphocyte differentiation. Recently the TNF family molecule osteoclast differentiation factor/receptor activator of NF-kappaB ligand (ODF/RANKL) was identified as a key membrane-associated factor regulating osteoclast differentiation. We demonstrate that B-lymphoid lineage cells are a major source of endogenous ODF/RANKL in bone marrow and support osteoclast differentiation in vitro. In addition, B-lymphoid lineage cells in earlier developmental stages may hold a potential to differentiate into osteoclasts when stimulated with M-CSF and soluble ODF/RANKL in vitro. B-lymphoid lineage cells may participate in osteoclastogenesis in two ways: they 1) express ODF/RANKL to support osteoclast differentiation, and 2) serve themselves as osteoclast progenitors. Consistent with these observations in vitro, a decrease in osteoclasts is associated with a decrease in B-lymphoid cells in klotho mutant mice (KL(-/-)), a mouse model for human aging that exhibits reduced turnover during bone metabolism, rather than a decrease in the differentiation potential of osteoclast progenitors. Taken together, B-lymphoid lineage cells may affect the pathophysiology of bone disorders through regulating osteoclastogenesis. | lld:pubmed |
| pubmed-article:11509604 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11509604 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11509604 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:11509604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11509604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11509604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11509604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11509604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11509604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11509604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11509604 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11509604 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:11509604 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:11509604 | pubmed:author | pubmed-author:InadaMM | lld:pubmed |
| pubmed-article:11509604 | pubmed:author | pubmed-author:ManabeNN | lld:pubmed |
| pubmed-article:11509604 | pubmed:author | pubmed-author:NakamuraKK | lld:pubmed |
| pubmed-article:11509604 | pubmed:author | pubmed-author:KawaguchiHH | lld:pubmed |
| pubmed-article:11509604 | pubmed:author | pubmed-author:NagaiRR | lld:pubmed |
| pubmed-article:11509604 | pubmed:author | pubmed-author:MiyauraCC | lld:pubmed |
| pubmed-article:11509604 | pubmed:author | pubmed-author:ScheuermannR... | lld:pubmed |
| pubmed-article:11509604 | pubmed:author | pubmed-author:Kuro-oMM | lld:pubmed |
| pubmed-article:11509604 | pubmed:author | pubmed-author:SinclairA MAM | lld:pubmed |
| pubmed-article:11509604 | pubmed:author | pubmed-author:ChikudaHH | lld:pubmed |
| pubmed-article:11509604 | pubmed:author | pubmed-author:Nabeshima YY | lld:pubmed |
| pubmed-article:11509604 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11509604 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11509604 | pubmed:volume | 167 | lld:pubmed |
| pubmed-article:11509604 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11509604 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11509604 | pubmed:pagination | 2625-31 | lld:pubmed |
| pubmed-article:11509604 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11509604 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11509604 | pubmed:articleTitle | Connection between B lymphocyte and osteoclast differentiation pathways. | lld:pubmed |
| pubmed-article:11509604 | pubmed:affiliation | Department of Orthopaedic Surgery and Cardiovascular Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan. | lld:pubmed |
| pubmed-article:11509604 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11509604 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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