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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2001-8-17
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pubmed:abstractText |
Osteoclasts differentiate from the hemopoietic monocyte/macrophage cell lineage in bone marrow through cell-cell interactions between osteoclast progenitors and stromal/osteoblastic cells. Here we show another osteoclast differentiation pathway closely connected with B lymphocyte differentiation. Recently the TNF family molecule osteoclast differentiation factor/receptor activator of NF-kappaB ligand (ODF/RANKL) was identified as a key membrane-associated factor regulating osteoclast differentiation. We demonstrate that B-lymphoid lineage cells are a major source of endogenous ODF/RANKL in bone marrow and support osteoclast differentiation in vitro. In addition, B-lymphoid lineage cells in earlier developmental stages may hold a potential to differentiate into osteoclasts when stimulated with M-CSF and soluble ODF/RANKL in vitro. B-lymphoid lineage cells may participate in osteoclastogenesis in two ways: they 1) express ODF/RANKL to support osteoclast differentiation, and 2) serve themselves as osteoclast progenitors. Consistent with these observations in vitro, a decrease in osteoclasts is associated with a decrease in B-lymphoid cells in klotho mutant mice (KL(-/-)), a mouse model for human aging that exhibits reduced turnover during bone metabolism, rather than a decrease in the differentiation potential of osteoclast progenitors. Taken together, B-lymphoid lineage cells may affect the pathophysiology of bone disorders through regulating osteoclastogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronidase,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RANK Ligand,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Activator of Nuclear...,
http://linkedlifedata.com/resource/pubmed/chemical/TNFRSF11A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TNFSF11 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfrsf11a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfsf11 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/klotho protein
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-1767
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pubmed:author |
pubmed-author:ChikudaHH,
pubmed-author:InadaMM,
pubmed-author:KawaguchiHH,
pubmed-author:Kuro-oMM,
pubmed-author:ManabeNN,
pubmed-author:MiyauraCC,
pubmed-author:Nabeshima YY,
pubmed-author:NagaiRR,
pubmed-author:NakamuraKK,
pubmed-author:ScheuermannR HRH,
pubmed-author:SinclairA MAM
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
167
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2625-31
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11509604-Aging,
pubmed-meshheading:11509604-Animals,
pubmed-meshheading:11509604-B-Lymphocytes,
pubmed-meshheading:11509604-Base Sequence,
pubmed-meshheading:11509604-Carrier Proteins,
pubmed-meshheading:11509604-Cell Differentiation,
pubmed-meshheading:11509604-DNA Primers,
pubmed-meshheading:11509604-Glucuronidase,
pubmed-meshheading:11509604-Hematopoietic Stem Cells,
pubmed-meshheading:11509604-Humans,
pubmed-meshheading:11509604-Membrane Glycoproteins,
pubmed-meshheading:11509604-Membrane Proteins,
pubmed-meshheading:11509604-Mice,
pubmed-meshheading:11509604-Mice, Inbred C3H,
pubmed-meshheading:11509604-Mice, Inbred C57BL,
pubmed-meshheading:11509604-Mice, Knockout,
pubmed-meshheading:11509604-Osteoclasts,
pubmed-meshheading:11509604-Osteoporosis,
pubmed-meshheading:11509604-RANK Ligand,
pubmed-meshheading:11509604-Receptor Activator of Nuclear Factor-kappa B
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pubmed:year |
2001
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pubmed:articleTitle |
Connection between B lymphocyte and osteoclast differentiation pathways.
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pubmed:affiliation |
Department of Orthopaedic Surgery and Cardiovascular Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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