Source:http://linkedlifedata.com/resource/pubmed/id/11509529
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2001-8-17
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| pubmed:abstractText |
Carotid body denervation (CBD) in neonatal goats and piglets results in minimal irregular breathing and no fatalities. Redundancy and/or plasticity of peripheral chemosensitivity and a relatively mature ventilatory control system at birth may contribute to the paucity of CBD effects in these species. In the present study, we tested the hypothesis that CBD mortality would be greater in neonates of a less mature species such as the rat. We found that the mortality in rats denervated at 2-3 and 7-8 days of age was significantly higher (P < 0.05) than in sham-CBD rats. In all surviving rats, pulmonary ventilation during hypoxia was lower in CBD than in sham operated rats 2 days after denervation. In surviving rats denervated during the 7th and 8th postnatal days, there was also reduced weight gain and pulmonary ventilation during eupnea, including apneas up to 20 s in duration. However, the effects of CBD were compensated within 3 wk after denervation. Local injections of NaCN indicated that aortic chemoreceptors might have been one of the sites of recovery of peripheral chemosensitivity. We concluded that CBD has higher mortality in newborn rats than in other mammals, possibly because of the relative immaturity of these animals at birth. Nonetheless, in survivors there was enough redundancy and plasticity in the control of breathing to eventually compensate for the consequences of CBD.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
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| pubmed:issn |
8750-7587
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
91
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1298-306
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:11509529-Age Factors,
pubmed-meshheading:11509529-Animals,
pubmed-meshheading:11509529-Animals, Newborn,
pubmed-meshheading:11509529-Anoxia,
pubmed-meshheading:11509529-Body Temperature,
pubmed-meshheading:11509529-Carbon Dioxide,
pubmed-meshheading:11509529-Carotid Body,
pubmed-meshheading:11509529-Denervation,
pubmed-meshheading:11509529-Female,
pubmed-meshheading:11509529-Hypercapnia,
pubmed-meshheading:11509529-Neuronal Plasticity,
pubmed-meshheading:11509529-Poisons,
pubmed-meshheading:11509529-Pregnancy,
pubmed-meshheading:11509529-Rats,
pubmed-meshheading:11509529-Rats, Sprague-Dawley,
pubmed-meshheading:11509529-Respiration,
pubmed-meshheading:11509529-Sodium Cyanide,
pubmed-meshheading:11509529-Species Specificity,
pubmed-meshheading:11509529-Survival Rate
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Mortality after carotid body denervation in rats.
|
| pubmed:affiliation |
Department of Physiology, Medical College of Wisconsin and Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53226-0509, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|