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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2001-8-17
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pubmed:abstractText |
The mammalian BAF complex regulates gene expression by modifying chromatin structure. In this report, we identify 80 genes activated and 2 genes repressed by the BAF complex in SW-13 cells. We find that prior binding of NFI/CTF to the NFI/CTF binding site in CSF1 promoter is required for the recruitment of the BAF complex and the BAF-dependent activation of the promoter. Furthermore, the activation of the CSF1 promoter requires Z-DNA-forming sequences that are converted to Z-DNA structure upon activation by the BAF complex. The BAF complex facilitates Z-DNA formation in a nucleosomal template in vitro. We propose a model in which the BAF complex promotes Z-DNA formation which, in turn, stabilizes the open chromatin structure at the CSF1 promoter.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCAAT-Enhancer-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CTF-1 transcription factor,
http://linkedlifedata.com/resource/pubmed/chemical/Chromatin,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Superhelical,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Helicases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Macromolecular Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Colony-Stimulating Factor,
http://linkedlifedata.com/resource/pubmed/chemical/NFI Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Subunits,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/SMARCA2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/SMARCA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
309-18
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11509180-Base Sequence,
pubmed-meshheading:11509180-CCAAT-Enhancer-Binding Proteins,
pubmed-meshheading:11509180-Chromatin,
pubmed-meshheading:11509180-DNA, Superhelical,
pubmed-meshheading:11509180-DNA Helicases,
pubmed-meshheading:11509180-DNA-Binding Proteins,
pubmed-meshheading:11509180-Gene Expression Profiling,
pubmed-meshheading:11509180-Gene Expression Regulation,
pubmed-meshheading:11509180-Gene Silencing,
pubmed-meshheading:11509180-Humans,
pubmed-meshheading:11509180-Macromolecular Substances,
pubmed-meshheading:11509180-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:11509180-Models, Genetic,
pubmed-meshheading:11509180-Molecular Sequence Data,
pubmed-meshheading:11509180-NFI Transcription Factors,
pubmed-meshheading:11509180-Nuclear Proteins,
pubmed-meshheading:11509180-Nucleic Acid Conformation,
pubmed-meshheading:11509180-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:11509180-Plasmids,
pubmed-meshheading:11509180-Promoter Regions, Genetic,
pubmed-meshheading:11509180-Protein Binding,
pubmed-meshheading:11509180-Protein Subunits,
pubmed-meshheading:11509180-RNA, Messenger,
pubmed-meshheading:11509180-Response Elements,
pubmed-meshheading:11509180-Templates, Genetic,
pubmed-meshheading:11509180-Transcription Factors,
pubmed-meshheading:11509180-Transcriptional Activation,
pubmed-meshheading:11509180-Tumor Cells, Cultured
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pubmed:year |
2001
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pubmed:articleTitle |
Regulation of CSF1 promoter by the SWI/SNF-like BAF complex.
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pubmed:affiliation |
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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