Linked Life Data

11508868

Source:http://linkedlifedata.com/resource/pubmed/id/11508868

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-8-17
pubmed:abstractText
The aim of this study was to compare the ability of various microorganisms to translocate from the intestine to the mesenteric lymph nodes (MLNs), liver, and spleen in a burned mouse model. Balb/c mice were gavaged with 1 x 10(9) or 1 x 10(10) of one of 11 different microorganisms. All animals were then given a 20% burn. Survival after 10 days showed no significant difference between any of the groups at the 10(10) dose. At the 10(9) dose, significantly higher survival rates were found in three of the 11 strains. Microbial translocation (gavage of 10(10) 111In-labeled organisms) and host's ability to kill translocated bacteria (viable bacteria in tissues) were measured followed by burn injury and sacrifice four hours later. Translocation and killing of Staphylococcus epidermidis and Escherichia coli was high in the MLNs compared with all other groups but translocation was lower to the liver. Klebsiella, Pseudomonas, and Serratia translocated more evenly to all the tissues. However, these groups showed very high clearance of bacteria in the liver and spleen except for Klebsiella and one strain of Pseudomonas in the spleen. Candida showed poor translocation to all of the tissues and high clearance. It is concluded that various strains of bacteria translocate from the intestine to a similar degree after injury, but the tissues to which they translocate and the rate at which they are killed are somewhat strain dependent.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1073-2322
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
148-52
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Comparison of translocation of different types of microorganisms from the intestinal tract of burned mice.
pubmed:affiliation
Department of Surgery, University of Cincinnati College of Medicine and the Shriners Burns Institute, Ohio 45267-0558, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't