Linked Life Data

11508506

Source:http://linkedlifedata.com/resource/pubmed/id/11508506

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2001-8-17
pubmed:abstractText
Previous studies have shown that pressure changes in the cerebrospinal fluid compartment are transmitted to the inner ear. The main route for pressure transfer is the cochlear aqueduct. about which little is known with regard to its dynamic properties. In the present study, sudden intracranial pressure changes (square waves and short pulses) were created in guinea pigs by means of an electronically controlled infusion system. Simultaneously with pressure manipulation, hydrostatic pressure was monitored in both the peridural space and the perilymphatic compartment of the inner ear. The onset of an inner ear pressure change following manipulation of intracranial pressure was immediate. Inner ear pressure increased or decreased without a measurable time lag, and equalized within a few seconds. During square wave intracranial pressure manipulation, inner ear pressure equalized somewhat more slowly after pressure increase than after pressure decrease. To a first approximation, the pressure equalization curves for the inner ear could be fitted with a single exponential function, rising or falling with a time constant in the range 1-3 s, and the system can be described as a low-pass filter composed of a constant compliance and a constant flow resistance. Detailed analysis, however, showed small deviations from a purely exponential recovery process. With a more complicated (non-linear) model, almost perfect fits to the inner ear pressure equalization curves could be obtained. This non-linearity may be a consequence of the dependence of the compliance and, or flow resistance on pressure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0001-6489
pubmed:author
pubmed:issnType
Print
pubmed:volume
121
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
470-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Dynamics of inner ear pressure change caused by intracranial pressure manipulation in the guinea pig.
pubmed:affiliation
Department of Otorhinolaryngology, University Hospital Groningen, The Netherlands. e.o.thalen@kno.azg.nl
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't