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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2001-8-17
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pubmed:abstractText |
The location of nephrin has been identified as the slit-diaphragm of the glomerular podocyte. Recent evidence suggests that nephrin could play a key role in the function of the glomerular filtration barrier and the development of proteinuria but its status in long-term diabetes is still not understood. We studied the expression of nephrin in a hypertensive model of diabetic nephropathy and investigated the potential influence of angiotensin II blockade on nephrin gene and protein expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0012-186X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
874-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11508272-Albuminuria,
pubmed-meshheading:11508272-Analysis of Variance,
pubmed-meshheading:11508272-Angiotensin Receptor Antagonists,
pubmed-meshheading:11508272-Animals,
pubmed-meshheading:11508272-Biphenyl Compounds,
pubmed-meshheading:11508272-Diabetes Mellitus, Experimental,
pubmed-meshheading:11508272-Disease Models, Animal,
pubmed-meshheading:11508272-Gene Expression Regulation,
pubmed-meshheading:11508272-Hypertension,
pubmed-meshheading:11508272-Male,
pubmed-meshheading:11508272-Membrane Proteins,
pubmed-meshheading:11508272-Oligonucleotide Probes,
pubmed-meshheading:11508272-Proteins,
pubmed-meshheading:11508272-Rats,
pubmed-meshheading:11508272-Rats, Inbred SHR,
pubmed-meshheading:11508272-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:11508272-Tetrazoles
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pubmed:year |
2001
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pubmed:articleTitle |
Irbesartan normalises the deficiency in glomerular nephrin expression in a model of diabetes and hypertension.
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pubmed:affiliation |
Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg West, Victoria, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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