Source:http://linkedlifedata.com/resource/pubmed/id/11506998
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2001-8-16
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| pubmed:abstractText |
Interleukin (IL)-1beta is involved in physiological sleep regulation. IL-18 is a member of the IL-1 family, and its signal-transduction mechanism is similar to that of IL-1. Therefore, we hypothesized that IL-18 might also be involved in sleep regulation. Three doses of IL-18 (10, 100, and 500 ng) were injected intracerebroventricularly (icv) into rabbits at the onset of the dark period. The two higher doses of IL-18 markedly increased non-rapid eye movement sleep (NREMS), accompanied by increases in brain temperature (Tbr). These effects were lost after the heat inactivation of IL-18. The 500 ng of IL-18 injection during the light period also increased NREMS and Tbr. Similar results were obtained after icv injection of 100 ng of IL-18 into rats. Furthermore, intraperitoneal injection of 30 microg/kg of IL-18 slightly, but significantly, increased NREMS, whereas it significantly decreased electroencephalogram slow-wave activity in rats. Intraperitoneal IL-18 failed to induce fever. An anti-human IL-18 antibody had little effect on spontaneous sleep in rabbits, although the anti-IL-18 antibody significantly attenuated muramyl dipeptide-induced sleep. These data suggest that IL-18 is involved in mechanisms of sleep responses to infection.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
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| pubmed:issn |
0363-6119
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
281
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
R828-38
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:11506998-Acetylmuramyl-Alanyl-Isoglutamine,
pubmed-meshheading:11506998-Animals,
pubmed-meshheading:11506998-Antibodies,
pubmed-meshheading:11506998-Body Temperature,
pubmed-meshheading:11506998-Brain,
pubmed-meshheading:11506998-Darkness,
pubmed-meshheading:11506998-Dose-Response Relationship, Drug,
pubmed-meshheading:11506998-Electroencephalography,
pubmed-meshheading:11506998-Fever,
pubmed-meshheading:11506998-Injections, Intraperitoneal,
pubmed-meshheading:11506998-Injections, Intraventricular,
pubmed-meshheading:11506998-Interleukin-18,
pubmed-meshheading:11506998-Light,
pubmed-meshheading:11506998-Male,
pubmed-meshheading:11506998-Photoperiod,
pubmed-meshheading:11506998-Rabbits,
pubmed-meshheading:11506998-Rats,
pubmed-meshheading:11506998-Rats, Sprague-Dawley,
pubmed-meshheading:11506998-Signal Transduction,
pubmed-meshheading:11506998-Sleep,
pubmed-meshheading:11506998-Sleep Stages,
pubmed-meshheading:11506998-Specific Pathogen-Free Organisms
|
| pubmed:year |
2001
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| pubmed:articleTitle |
Interleukin-18 promotes sleep in rabbits and rats.
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| pubmed:affiliation |
College of Veterinary Medicine, Department of VCAPP, Washington State University, Pullman, WA 99164-6520, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|